Sesquiterpene Lactones as Promising Anti-Glioblastoma Drug Candidates Exerting Complex Effects on Glioblastoma Cell Viability and Proneural–Mesenchymal Transition

Sesquiterpene Lactones as Promising Anti-Glioblastoma Drug Candidates Exerting Complex Effects on Glioblastoma Cell Viability and Proneural–Mesenchymal Transition

Glioblastoma is one of the most aggressive brain cancers, characterized by active infiltrative growth and high resistance to radiotherapy and chemotherapy. Sesquiterpene triterpenoids (STLs) and their semi-synthetic analogs are considered as a promising source of novel anti-tumor agents due to their...

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Bibliographic Details
Main Authors: Andrey V. Markov, Arseny D. Moralev, Kirill V. Odarenko
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Biomedicines
Subjects:
brain tumor
terpenes
tumor cell death
mitochondrial dysfunction
epithelial–mesenchymal transition
glial–mesenchymal transition
Online Access:https://www.mdpi.com/2227-9059/13/1/133
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