Ionophore-based potentiometric PVC membrane sensors for determination of phenobarbitone in pharmaceutical formulations
The fabrication and development of two polyvinyl chloride (PVC) membrane sensors for assaying phenobarbitone sodium are described. Sensors 1 and 2 were fabricated utilizing β- or γ-cyclodextrin as ionophore in the presence of tridodecylmethylammonium chloride as a membrane additive, and PVC and dioc...
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| Format: | Article |
| Language: | English |
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Sciendo
2016-12-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.1515/acph-2016-0042 |
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| author | Alrabiah Haitham Al-Majed Abdulrahman Abounassif Mohammed Mostafa Gamal A.E. |
| author_facet | Alrabiah Haitham Al-Majed Abdulrahman Abounassif Mohammed Mostafa Gamal A.E. |
| author_sort | Alrabiah Haitham |
| collection | DOAJ |
| description | The fabrication and development of two polyvinyl chloride (PVC) membrane sensors for assaying phenobarbitone sodium are described. Sensors 1 and 2 were fabricated utilizing β- or γ-cyclodextrin as ionophore in the presence of tridodecylmethylammonium chloride as a membrane additive, and PVC and dioctyl phthalate as plasticizer. The analytical parameters of both sensors were evaluated according to the IUPAC guidelines. The proposed sensors showed rapid, stable anionic response (-59.1 and -62.0 mV per decade) over a relatively wide phenobarbitone concentration range (5.0 × 10-6-1 × 10-2 and 8 × 10-6-1 × 10-2 mol L-1) in the pH range of 9-11. The limit of detection was 3.5 × 10-6 and 7.0 × 10-6 mol L-1 for sensors 1 and 2, respectively. The fabricated sensors showed high selectivity for phenobarbitone over the investigated foreign species. An average recovery of 2.54 μg mL-1 phenobarbitone sodium was 97.4 and 101.1 %, while the mean relative standard deviation was 3.0 and 2.1 %, for sensors 1 and 2, respectively. The results acquired for determination of phenobarbitone in its dosage forms utilizing the proposed sensors are in good agreement with those obtained by the British Pharmacopoeial method. |
| format | Article |
| id | doaj-art-33a1c8c82b954287b68305ff0d1762d7 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2016-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-33a1c8c82b954287b68305ff0d1762d72025-02-02T09:57:54ZengSciendoActa Pharmaceutica1846-95582016-12-0166450351410.1515/acph-2016-0042acph-2016-0042Ionophore-based potentiometric PVC membrane sensors for determination of phenobarbitone in pharmaceutical formulationsAlrabiah Haitham0Al-Majed Abdulrahman1Abounassif Mohammed2Mostafa Gamal A.E.3Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, P.O.Box, 2457, Riyadh 11451, Saudi ArabiaPharmaceutical Chemistry Department, College of Pharmacy, King Saud University, P.O.Box, 2457, Riyadh 11451, Saudi ArabiaPharmaceutical Chemistry Department, College of Pharmacy, King Saud University, P.O.Box, 2457, Riyadh 11451, Saudi ArabiaPharmaceutical Chemistry Department, College of Pharmacy, King Saud University, P.O.Box, 2457, Riyadh 11451, Saudi Arabia EgyptThe fabrication and development of two polyvinyl chloride (PVC) membrane sensors for assaying phenobarbitone sodium are described. Sensors 1 and 2 were fabricated utilizing β- or γ-cyclodextrin as ionophore in the presence of tridodecylmethylammonium chloride as a membrane additive, and PVC and dioctyl phthalate as plasticizer. The analytical parameters of both sensors were evaluated according to the IUPAC guidelines. The proposed sensors showed rapid, stable anionic response (-59.1 and -62.0 mV per decade) over a relatively wide phenobarbitone concentration range (5.0 × 10-6-1 × 10-2 and 8 × 10-6-1 × 10-2 mol L-1) in the pH range of 9-11. The limit of detection was 3.5 × 10-6 and 7.0 × 10-6 mol L-1 for sensors 1 and 2, respectively. The fabricated sensors showed high selectivity for phenobarbitone over the investigated foreign species. An average recovery of 2.54 μg mL-1 phenobarbitone sodium was 97.4 and 101.1 %, while the mean relative standard deviation was 3.0 and 2.1 %, for sensors 1 and 2, respectively. The results acquired for determination of phenobarbitone in its dosage forms utilizing the proposed sensors are in good agreement with those obtained by the British Pharmacopoeial method.https://doi.org/10.1515/acph-2016-0042phenobarbitone sodiummembrane selective electrodeβ-cyclodextrinγ-cyclodextrinpvcpotentiometry |
| spellingShingle | Alrabiah Haitham Al-Majed Abdulrahman Abounassif Mohammed Mostafa Gamal A.E. Ionophore-based potentiometric PVC membrane sensors for determination of phenobarbitone in pharmaceutical formulations Acta Pharmaceutica phenobarbitone sodium membrane selective electrode β-cyclodextrin γ-cyclodextrin pvc potentiometry |
| title | Ionophore-based potentiometric PVC membrane sensors for determination of phenobarbitone in pharmaceutical formulations |
| title_full | Ionophore-based potentiometric PVC membrane sensors for determination of phenobarbitone in pharmaceutical formulations |
| title_fullStr | Ionophore-based potentiometric PVC membrane sensors for determination of phenobarbitone in pharmaceutical formulations |
| title_full_unstemmed | Ionophore-based potentiometric PVC membrane sensors for determination of phenobarbitone in pharmaceutical formulations |
| title_short | Ionophore-based potentiometric PVC membrane sensors for determination of phenobarbitone in pharmaceutical formulations |
| title_sort | ionophore based potentiometric pvc membrane sensors for determination of phenobarbitone in pharmaceutical formulations |
| topic | phenobarbitone sodium membrane selective electrode β-cyclodextrin γ-cyclodextrin pvc potentiometry |
| url | https://doi.org/10.1515/acph-2016-0042 |
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