Intrapericardial injection of hydrogels with ASC and their secretome to treat dilated cardiomyopathies

Intrapericardial injection of hydrogels with ASC and their secretome to treat dilated cardiomyopathies

Abstract Doxorubicin-induced cardiomyopathy (DOX-IC) is a significant and common complication in patients undergoing chemotherapy, leading to cardiac remodeling and reduced heart function. We hypothesized that the intrapericardial injection of hydrogels derived from the cardiac decellularized extrac...

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Main Authors: Tácia Tavares Aquinas Liguori, Gabriel Romero Liguori, Viktor Sinkunas, Cristiano Jesus Correia, Raphael dos Santos Coutinho e Silva, Fernando Luiz Zanoni, Vera Demarchi Aiello, Martin Conrad Harmsen, Luiz Felipe Pinho Moreira
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Dilated cardiomyopathy (DCM)
Doxorubicin
Extracellular matrix
Hydrogels
Stem cells
Cell therapy
Online Access:https://doi.org/10.1038/s41598-025-87939-z
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