AM1241 inhibits chondrocyte inflammation and ECM degradation through the Nrf2/HO-1 and NF-κB pathways and alleviates osteoarthritis in mice

AM1241 inhibits chondrocyte inflammation and ECM degradation through the Nrf2/HO-1 and NF-κB pathways and alleviates osteoarthritis in mice

Abstract Background This study aimed to investigate the impact of AM1241 on lipopolysaccharide (LPS)-induced chondrocyte inflammation in mice and its potential mechanism for improving osteoarthritis (OA). Methods The OA mice model was established employing the refined Hulth method. The impact of dif...

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Bibliographic Details
Main Authors: Zhuan Zou, Songmu Pan, Changzheng Sun, Jiyong Wei, Yi Xu, Kaizhen Xiao, Jinmin Zhao, Ronghe Gu
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Molecular Medicine
Subjects:
Osteoarthritis
AM1241
Lipopolysaccharide
Chondrocyte
Inflammation
Molecular docking
Online Access:https://doi.org/10.1186/s10020-024-01012-5
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https://doi.org/10.1186/s10020-024-01012-5

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