Evidence for the Gut Microbiota Short-Chain Fatty Acids as Key Pathophysiological Molecules Improving Diabetes
In type 2 diabetes, hyperglycemia, insulin resistance, increased inflammation, and oxidative stress were shown to be associated with the progressive deterioration of beta-cell function and mass. Short-chain fatty acids (SCFAs) are organic fatty acids produced in the distal gut by bacterial fermentat...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/162021 |
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| author | Alessandra Puddu Roberta Sanguineti Fabrizio Montecucco Giorgio Luciano Viviani |
| author_facet | Alessandra Puddu Roberta Sanguineti Fabrizio Montecucco Giorgio Luciano Viviani |
| author_sort | Alessandra Puddu |
| collection | DOAJ |
| description | In type 2 diabetes, hyperglycemia, insulin resistance, increased inflammation, and oxidative stress were shown to be associated with the progressive deterioration of beta-cell function and mass. Short-chain fatty acids (SCFAs) are organic fatty acids produced in the distal gut by bacterial fermentation of macrofibrous material that might improve type 2 diabetes features. Their main beneficial activities were identified in the decrease of serum levels of glucose, insulin resistance as well as inflammation, and increase in protective Glucagon-like peptide-1 (GLP-1) secretion. In this review, we updated evidence on the effects of SCFAs potentially improving metabolic control in type 2 diabetes. |
| format | Article |
| id | doaj-art-334d76b2428e42c7ac0d9b34d4f7d131 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-334d76b2428e42c7ac0d9b34d4f7d1312025-02-03T06:06:12ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/162021162021Evidence for the Gut Microbiota Short-Chain Fatty Acids as Key Pathophysiological Molecules Improving DiabetesAlessandra Puddu0Roberta Sanguineti1Fabrizio Montecucco2Giorgio Luciano Viviani3First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, IRCCS Azienda Ospedaliera Universitaria San Martino, 6 Viale Benedetto XV, 16143 Genoa, ItalyFirst Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, IRCCS Azienda Ospedaliera Universitaria San Martino, 6 Viale Benedetto XV, 16143 Genoa, ItalyFirst Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, IRCCS Azienda Ospedaliera Universitaria San Martino, 6 Viale Benedetto XV, 16143 Genoa, ItalyFirst Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, IRCCS Azienda Ospedaliera Universitaria San Martino, 6 Viale Benedetto XV, 16143 Genoa, ItalyIn type 2 diabetes, hyperglycemia, insulin resistance, increased inflammation, and oxidative stress were shown to be associated with the progressive deterioration of beta-cell function and mass. Short-chain fatty acids (SCFAs) are organic fatty acids produced in the distal gut by bacterial fermentation of macrofibrous material that might improve type 2 diabetes features. Their main beneficial activities were identified in the decrease of serum levels of glucose, insulin resistance as well as inflammation, and increase in protective Glucagon-like peptide-1 (GLP-1) secretion. In this review, we updated evidence on the effects of SCFAs potentially improving metabolic control in type 2 diabetes.http://dx.doi.org/10.1155/2014/162021 |
| spellingShingle | Alessandra Puddu Roberta Sanguineti Fabrizio Montecucco Giorgio Luciano Viviani Evidence for the Gut Microbiota Short-Chain Fatty Acids as Key Pathophysiological Molecules Improving Diabetes Mediators of Inflammation |
| title | Evidence for the Gut Microbiota Short-Chain Fatty Acids as Key Pathophysiological Molecules Improving Diabetes |
| title_full | Evidence for the Gut Microbiota Short-Chain Fatty Acids as Key Pathophysiological Molecules Improving Diabetes |
| title_fullStr | Evidence for the Gut Microbiota Short-Chain Fatty Acids as Key Pathophysiological Molecules Improving Diabetes |
| title_full_unstemmed | Evidence for the Gut Microbiota Short-Chain Fatty Acids as Key Pathophysiological Molecules Improving Diabetes |
| title_short | Evidence for the Gut Microbiota Short-Chain Fatty Acids as Key Pathophysiological Molecules Improving Diabetes |
| title_sort | evidence for the gut microbiota short chain fatty acids as key pathophysiological molecules improving diabetes |
| url | http://dx.doi.org/10.1155/2014/162021 |
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