Aldosterone-Related Cardiovascular Disease and Benefits of Mineralocorticoid Receptor Antagonists in Clinical Practice

Aldosterone-Related Cardiovascular Disease and Benefits of Mineralocorticoid Receptor Antagonists in Clinical Practice

High levels of aldosterone are associated with vascular and cardiac remodeling, myocardial fibrosis, and endothelial dysfunction with consequent increased risk of cardiovascular events and cardiovascular mortality. Indeed, mineralcorticoid receptor antagonists (MRAs) are recommended in the treatment...

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Main Authors: Maria Alfarano, MD, PhD, Giulia Marchionni, MD, Jacopo Costantino, MD, Federico Ballatore, MD, Romina Verardo, PhD, Fabio Miraldi, MD, Francesco Luigi Ciciarello, MD, Luigi Petramala, MD, Claudio Letizia, MD, Andrea Frustaci, MD, Cristina Chimenti, MD, PhD
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:JACC: Advances
Subjects:
aldosterone
cardiomyopathy
endomyocardial biopsy
heart failure
mineralocorticoid receptor antagonists
molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2772963X25001796
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