Adventitial Fibroblasts Release Interleukin 6 After Vascular Injury and Induce Smooth Muscle Cell Proliferation and Neointima Formation

Adventitial Fibroblasts Release Interleukin 6 After Vascular Injury and Induce Smooth Muscle Cell Proliferation and Neointima Formation

Background Vascular restenosis resulting from neointima formation significantly limits the efficacy of percutaneous interventional therapies compared with bypass surgery. The adventitial layer is involved in neointima formation, but the detailed pathophysiological interplay of the different cell typ...

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Main Authors: Jochen Dutzmann, Jan‐Marcus Daniel, Laura Korte, Frederik J. Kloss, Kai Knöpp, Katrin Kalies, Kevin J. Croce, Thomas J. Herbst, Barbara Huibregtse, Felix J. Vogt, Stefan Offermanns, Johann Bauersachs, Daniel G. Sedding
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
adventitial fibroblasts
interleukin 6
neointima formation
paracrine signaling
smooth muscle cells
vascular restenosis
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.040143
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https://www.ahajournals.org/doi/10.1161/JAHA.124.040143

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