Bladder cancer subtypes exhibit limited plasticity across different microenvironments and in metastases

Bladder cancer subtypes exhibit limited plasticity across different microenvironments and in metastases

Abstract Background Transcriptomic and genomic analyses of bladder cancer (BC) reveal a highly diverse disease stratified into molecular subtypes with distinct molecular features and biological behaviors. Intratumor heterogeneity (ITH) and plasticity can significantly impact diagnosis and patient ma...

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Main Authors: Carina Bernardo, Subhayan Chattopadhyay, Natalie Andersson, Pontus Eriksson, Benjamin Medle, Lena Tran, Nour al dain Marzouka, Adam Mattsson, Aymeric Zadoroznyj, Malin Larsson, Fredrik Liedberg, Mattias Höglund, Gottfrid Sjödahl
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Experimental Hematology & Oncology
Subjects:
Bladder cancer
Plasticity
Molecular subtypes
Tumor microenvironment
Metastasis
Tumor evolution
Online Access:https://doi.org/10.1186/s40164-025-00682-z
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https://doi.org/10.1186/s40164-025-00682-z

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