Individualized functional brain mapping machine learning prediction of symptom-change resulting from selective kappa-opioid antagonism in an anhedonic sample from a Fast-Fail trial

Background: Anhedonia remains a difficult-to-treat symptom and has been associated with poor clinical course transdiagnostically. Here, we applied machine learning models to individualized neural patches derived from fMRI data during the Monetary Incentive Delay Task in anhedonic participants (N = 6...

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Bibliographic Details
Main Authors: Matthew D. Sacchet, Joseph L. Valenti, Poorvi Keshava, Shane W. Walsh, Moria J. Smoski, Andrew D. Krystal, Diego A. Pizzagalli
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Journal of Mood and Anxiety Disorders
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Online Access:http://www.sciencedirect.com/science/article/pii/S2950004425000239
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