Phenome-wide association of APOE alleles in the All of Us Research ProgramResearch in context

Phenome-wide association of APOE alleles in the All of Us Research ProgramResearch in context

Summary: Background: Apolipoprotein E (APOE) variation is associated with altered lipid metabolism, as well as cardiovascular and neurodegenerative disease. Prior studies are largely limited to European ancestry populations and differential risk by sex and ancestry has not been widely evaluated. Me...

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Main Authors: Ehsan Khajouei, Valentina Ghisays, Ignazio S. Piras, Kiana L. Martinez, Anthony T. Vicenti, Marcus Naymik, Preston Ngo, Tam C. Tran, Joshua C. Denny, Travis J. Wheeler, Matthew J. Huentelman, Eric M. Reiman, Jason H. Karnes
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:EBioMedicine
Subjects:
Apolipoprotein E
Phenome-wide association study
Health disparities
Alzheimer’s disease
Hypercholesterolaemia
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425002129
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http://www.sciencedirect.com/science/article/pii/S2352396425002129

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