Aberrant expression of collagen type X in solid tumor stroma is associated with EMT, immunosuppressive and pro-metastatic pathways, bone marrow stromal cell signatures, and poor survival prognosis

Aberrant expression of collagen type X in solid tumor stroma is associated with EMT, immunosuppressive and pro-metastatic pathways, bone marrow stromal cell signatures, and poor survival prognosis

Abstract Background Collagen type X (ColXα1, encoded by COL10A1) is expressed specifically in the cartilage-to-bone transition, in bone marrow cells, and in osteoarthritic (OA) cartilage. We have previously shown that ColXα1 is expressed in breast tumor stroma, correlates with tumor-infiltrating lym...

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Main Authors: Elliot H. H. Famili-Youth, Aryana Famili-Youth, Dongfang Yang, Ayesha Siddique, Elizabeth Y. Wu, Wenguang Liu, Murray B. Resnick, Qian Chen, Alexander S. Brodsky
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Cancer
Subjects:
Collagen type X
Tumor microenvironment
Breast cancer
Pancreatic cancer
Osteoarthritis
Online Access:https://doi.org/10.1186/s12885-025-13641-y
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https://doi.org/10.1186/s12885-025-13641-y

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