Integrative transcriptomic and single-cell analysis reveals IL27RA as a key immune regulator and therapeutic indicator in breast cancer

Integrative transcriptomic and single-cell analysis reveals IL27RA as a key immune regulator and therapeutic indicator in breast cancer

Abstract Background Interleukin-27 receptor alpha (IL27RA), a key subunit of the interleukin-27 receptor, plays an essential role in T cell–mediated immunity. However, its relevance in breast cancer and response to immunotherapy remains unexplored. Methods We integrated bulk and single-cell RNA sequ...

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Bibliographic Details
Main Authors: Yi Chen, Munawar Anwar, Xiaoli Wang, Boxiang Zhang, Binlin Ma
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Discover Oncology
Subjects:
Breast cancer
IL27RA,
Tumor immune microenvironment
Single-cell RNA sequencing,
Immunotherapy response
Online Access:https://doi.org/10.1007/s12672-025-02811-w
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https://doi.org/10.1007/s12672-025-02811-w

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