Smoldering oncolysis by foamy virus carrying CD19 as a CAR target escapes CAR T detection by genomic modification

Smoldering oncolysis by foamy virus carrying CD19 as a CAR target escapes CAR T detection by genomic modification

Chimeric antigen receptor (CAR) T cells have had limited success against solid tumors. Here, we used an oncolytic foamy virus (oFV) to display a model CAR target antigen (CD19) on tumors in combination with anti-CD19 CAR T cells. We generated oFV-Δbel2 and oFV-bel2 vectors to test the efficiency and...

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Bibliographic Details
Main Authors: Jason M. Tonne, Karol Budzik, Talia Fernandez Carrasco, Landon Ebbert, Jill Thompson, Rebecca Nace, Benjamin Kendall, Rosa M. Diaz, Stephen J. Russell, Richard G. Vile
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
CAR T-cell
Simian foamy virus
cancer
oncolytic virotherapy
viral vectors
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329924000948
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http://www.sciencedirect.com/science/article/pii/S2950329924000948

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