When DNA Repair Backfires – Trabectedin Induces DNA Breaks in Active Genes

When DNA Repair Backfires – Trabectedin Induces DNA Breaks in Active Genes

Many anticancer drugs are ineffective in tumors that have functional DNA repair mechanisms. In contrast, trabectedin, a tetrahydroisoquinoline alkaloid marine natural product, stands out as it is more lethal to cancer cells with active DNA repair, particularly transcription-coupled nucleotide excisi...

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Bibliographic Details
Main Authors: Vakil Takhaveev, Kook Son, Visesato Mor, Hobin Yu, Emma Dillier, Nicola Zilo, Nikolai J. L. Püllen, Dmitri Ivanov, Helle D. Ulrich, Shana J. Sturia, Orlando D. Schärer
Format: Article
Language:deu
Published: Swiss Chemical Society 2025-04-01
Series:CHIMIA
Subjects:
DNA repair
Genomics
Precision oncology
Trabectedin
Online Access:https://www.chimia.ch/chimia/article/view/7976
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