TORC1 autonomously controls its spatial partitioning via the Rag GTPase tether Tco89

TORC1 autonomously controls its spatial partitioning via the Rag GTPase tether Tco89

Summary: The eukaryotic target of rapamycin complex 1 (TORC1) kinase is a homeostatic regulator of growth, integrating nutritional cues at the endolysosomal compartment. Amino acids activate mammalian TORC1 (mTORC1) through the Rag GTPases that recruit it to lysosomes via a short domain within the m...

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Main Authors: Raffaele Nicastro, Marie-Pierre Péli-Gulli, Marco Caligaris, Malika Jaquenoud, Ladislav Dokládal, Josephine Alba, Farida Tripodi, Benjamin Pillet, Melanie Brunner, Michael Stumpe, Kenji Muneshige, Riko Hatakeyama, Jörn Dengjel, Claudio De Virgilio
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Cell Reports
Subjects:
CP: Molecular biology
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725004541
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http://www.sciencedirect.com/science/article/pii/S2211124725004541

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