Translational profiling reveals novel gene expression changes in the direct and indirect pathways in a mouse model of levodopa induced dyskinesia

Translational profiling reveals novel gene expression changes in the direct and indirect pathways in a mouse model of levodopa induced dyskinesia

IntroductionThe molecular mechanisms underlying L-dihydroxyphenylalanine (LDOPA) induced dyskinesia in Parkinson's disease are poorly understood. Here we employ two transgenic mouse lines, combining translating ribosomal affinity purification (TRAP) with bacterial artificial chromosome expressi...

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Bibliographic Details
Main Authors: Sabika Jafri, Mahdi Ghani, Natalie Stickle, Carl Virtanen, Lili-Naz Hazrati, Naomi P. Visanji
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Parkinson's disease
levodopa
dyskinesia
gene expression
MAPK pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2024.1477511/full
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https://www.frontiersin.org/articles/10.3389/fncel.2024.1477511/full

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