Hybrid pharmacophore-based design of novel 5-lipoxygenase inhibitors: Molecular docking and dynamics simulation studies

Hybrid pharmacophore-based design of novel 5-lipoxygenase inhibitors: Molecular docking and dynamics simulation studies

5-Lipoxygenase (5-LO) is a fatty acid oxygenase, that catalyses the biosynthesis of leukotrienes (LT). Evidence shows that triggering 5-LO expression underlying pathogenesis for various diseases. Therefore it was identified as one of the potential target to develop drugs against inflammatory related...

Full description

Saved in:
Bibliographic Details
Main Authors: Jia Chern Pang, Kit-Kay Mak, Mallikarjuna Rao Pichika, Vasudeva Rao Avupati
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Results in Materials
Subjects:
5-Lipoxygenase
Leukotriene (LT)
Hybrid pharmacophore design (HPD)
Molecular docking
Molecular dynamics
Drug-like properties
Online Access:http://www.sciencedirect.com/science/article/pii/S2590048X25000548
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S2590048X25000548

Similar Items