Tolerance in Kidney Transplantation: What Is on the B Side?
Regulatory B cells (Breg) are in the spotlight for their role in immune homeostasis maintenance and tolerance achievement as in the last years the correlation with functional and increased Breg numbers in autoimmune diseases and transplantation has been extensively proven. Their study is, however, i...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/8491956 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832563549922131968 |
|---|---|
| author | Laura Carreras-Planella Francesc E. Borràs Marcella Franquesa |
| author_facet | Laura Carreras-Planella Francesc E. Borràs Marcella Franquesa |
| author_sort | Laura Carreras-Planella |
| collection | DOAJ |
| description | Regulatory B cells (Breg) are in the spotlight for their role in immune homeostasis maintenance and tolerance achievement as in the last years the correlation with functional and increased Breg numbers in autoimmune diseases and transplantation has been extensively proven. Their study is, however, in its infancy with still little knowledge and consensus on their origin, phenotype, and mechanism of action. All this hampers the pursuit of an effective Breg induction method for therapeutic purposes. In this review we aim to summarize the studies on human Breg and their implication in kidney transplantation and to further discuss the issues surrounding therapeutic applications of this cell subset. |
| format | Article |
| id | doaj-art-321ca91a986b45c8a2ad981283b357e7 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-321ca91a986b45c8a2ad981283b357e72025-02-03T01:13:06ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/84919568491956Tolerance in Kidney Transplantation: What Is on the B Side?Laura Carreras-Planella0Francesc E. Borràs1Marcella Franquesa2REMAR-IVECAT Group, Health Science Research Institute Germans Trias i Pujol, Can Ruti Campus, Badalona, SpainREMAR-IVECAT Group, Health Science Research Institute Germans Trias i Pujol, Can Ruti Campus, Badalona, SpainREMAR-IVECAT Group, Health Science Research Institute Germans Trias i Pujol, Can Ruti Campus, Badalona, SpainRegulatory B cells (Breg) are in the spotlight for their role in immune homeostasis maintenance and tolerance achievement as in the last years the correlation with functional and increased Breg numbers in autoimmune diseases and transplantation has been extensively proven. Their study is, however, in its infancy with still little knowledge and consensus on their origin, phenotype, and mechanism of action. All this hampers the pursuit of an effective Breg induction method for therapeutic purposes. In this review we aim to summarize the studies on human Breg and their implication in kidney transplantation and to further discuss the issues surrounding therapeutic applications of this cell subset.http://dx.doi.org/10.1155/2016/8491956 |
| spellingShingle | Laura Carreras-Planella Francesc E. Borràs Marcella Franquesa Tolerance in Kidney Transplantation: What Is on the B Side? Mediators of Inflammation |
| title | Tolerance in Kidney Transplantation: What Is on the B Side? |
| title_full | Tolerance in Kidney Transplantation: What Is on the B Side? |
| title_fullStr | Tolerance in Kidney Transplantation: What Is on the B Side? |
| title_full_unstemmed | Tolerance in Kidney Transplantation: What Is on the B Side? |
| title_short | Tolerance in Kidney Transplantation: What Is on the B Side? |
| title_sort | tolerance in kidney transplantation what is on the b side |
| url | http://dx.doi.org/10.1155/2016/8491956 |
| work_keys_str_mv | AT lauracarrerasplanella toleranceinkidneytransplantationwhatisonthebside AT francesceborras toleranceinkidneytransplantationwhatisonthebside AT marcellafranquesa toleranceinkidneytransplantationwhatisonthebside |