High sensitivity detection of Hepatitis B virus RNA based on 3D-DNA nanomachine and protein nanopore sensing

High sensitivity detection of Hepatitis B virus RNA based on 3D-DNA nanomachine and protein nanopore sensing

Abstract Serum Hepatitis B virus (HBV) RNA serves as a non-invasive biomarker for monitoring chronic hepatitis B and guiding treatment decisions. However, current diagnostic tests relying on Reverse Transcription Quantitative Polymerase Chain Reaction (RT-qPCR) require centralized facilities and ted...

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Bibliographic Details
Main Authors: Shixin Yan, Chuipeng Kong, Jiazhe Cheng, Zhuoyun Tang, Ke Sun, Shanchuan Chen, Minghan Li, Chengyan Tao, Yue Li, Yanhua Zhao, Chuanmin Tao, Jia Geng, Feng Li
Format: Article
Language:English
Published: Springer 2025-08-01
Series:Molecular Biomedicine
Subjects:
3D-DNA nanomachine
Nanopore sensing
Hepatitis B virus RNA
ssDNA
Clinical detection
Online Access:https://doi.org/10.1186/s43556-025-00282-7
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https://doi.org/10.1186/s43556-025-00282-7

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