P2X7 receptor drives Th1 cell differentiation and controls the follicular helper T cell population to protect against Plasmodium chabaudi malaria.

P2X7 receptor drives Th1 cell differentiation and controls the follicular helper T cell population to protect against Plasmodium chabaudi malaria.

A complete understanding of the mechanisms underlying the acquisition of protective immunity is crucial to improve vaccine strategies to eradicate malaria. However, it is still unclear whether recognition of damage signals influences the immune response to Plasmodium infection. Adenosine triphosphat...

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Main Authors: Érika Machado de Salles, Maria Nogueira de Menezes, Renan Siqueira, Henrique Borges da Silva, Eduardo Pinheiro Amaral, Sheyla Inés Castillo-Méndez, Isabela Cunha, Alexandra Dos Anjos Cassado, Flávia Sarmento Vieira, David Nicholas Olivieri, Carlos Eduardo Tadokoro, José Maria Alvarez, Robson Coutinho-Silva, Maria Regina D'Império-Lima
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-08-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006595&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006595&type=printable

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