A case report of anaplastic thyroid carcinoma transformed from small papillary carcinoma successfully detected by ultrasonography in its early stage with review of literature
An 82-year-old woman was referred to our hospital because of a suspicious thyroid nodule. She was diagnosed with papillary microcarcinoma with a maximum diameter of 9 mm based on ultrasonography and fine-needle aspiration (FNA) cytology. She preferred observation without surgery. Her papillary carci...
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The Japan Endocrine Society
2023-11-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/70/11/70_EJ23-0197/_html/-char/en |
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| author | Hiroshi Arimitsu Yui Nishijima Naoyuki Higaki Hitoshi Noguchi Shinya Uchino Tsukasa Murakami |
| author_facet | Hiroshi Arimitsu Yui Nishijima Naoyuki Higaki Hitoshi Noguchi Shinya Uchino Tsukasa Murakami |
| author_sort | Hiroshi Arimitsu |
| collection | DOAJ |
| description | An 82-year-old woman was referred to our hospital because of a suspicious thyroid nodule. She was diagnosed with papillary microcarcinoma with a maximum diameter of 9 mm based on ultrasonography and fine-needle aspiration (FNA) cytology. She preferred observation without surgery. Her papillary carcinoma grew gradually and reached a maximum diameter of 19 mm after 23 months. At that time, ultrasonography showed an apparent change in the shape of the nodule as well as in its diameter. At the initial ultrasound examination, papillary microcarcinoma was demonstrated as a hypoechoic solid nodule with an irregular shape. No punctuate microcalcifications were shown. After 23 months, the preexisting nodule had expanded toward the common carotid artery. The expanded portion was round and well demarcated. FNA revealed that the expanded portion consisted of anaplastic thyroid carcinoma. She underwent hemithyroidectomy and lymph node dissection of the central compartment. She remained in good health for 18 months after surgery. Anaplastic thyroid carcinoma is generally found as an aggressive large tumor, and the ultrasound appearance of small anaplastic thyroid carcinoma is poorly understood at present. We successfully detected anaplastic transformation in the early period by ultrasonography and FNA. When observation is indicated for small papillary thyroid carcinoma, the change in the shape of the nodule as well as in its diameter should be carefully monitored by ultrasonography. FNA should be performed at a proper site on the nodule to avoid overlooking anaplastic transformation, as resection following the early detection of anaplastic transformation might bring a favorable prognosis. |
| format | Article |
| id | doaj-art-31dbb9fd90c94c8c95e83e9e0e1f3234 |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-31dbb9fd90c94c8c95e83e9e0e1f32342025-01-22T06:23:18ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402023-11-0170111097110110.1507/endocrj.EJ23-0197endocrjA case report of anaplastic thyroid carcinoma transformed from small papillary carcinoma successfully detected by ultrasonography in its early stage with review of literatureHiroshi Arimitsu0Yui Nishijima1Naoyuki Higaki2Hitoshi Noguchi3Shinya Uchino4Tsukasa Murakami5Department of Endocrinology, Noguchi Thyroid Clinic and Hospital Foundation, Oita 874-0902, JapanDepartment of Endocrinology, Noguchi Thyroid Clinic and Hospital Foundation, Oita 874-0902, JapanDepartment of Endocrinology, Noguchi Thyroid Clinic and Hospital Foundation, Oita 874-0902, JapanDepartment of Endocrinology, Noguchi Thyroid Clinic and Hospital Foundation, Oita 874-0902, JapanDepartment of Endocrine Surgery, Noguchi Thyroid Clinic and Hospital Foundation, Oita 874-0902, JapanDepartment of Endocrinology, Noguchi Thyroid Clinic and Hospital Foundation, Oita 874-0902, JapanAn 82-year-old woman was referred to our hospital because of a suspicious thyroid nodule. She was diagnosed with papillary microcarcinoma with a maximum diameter of 9 mm based on ultrasonography and fine-needle aspiration (FNA) cytology. She preferred observation without surgery. Her papillary carcinoma grew gradually and reached a maximum diameter of 19 mm after 23 months. At that time, ultrasonography showed an apparent change in the shape of the nodule as well as in its diameter. At the initial ultrasound examination, papillary microcarcinoma was demonstrated as a hypoechoic solid nodule with an irregular shape. No punctuate microcalcifications were shown. After 23 months, the preexisting nodule had expanded toward the common carotid artery. The expanded portion was round and well demarcated. FNA revealed that the expanded portion consisted of anaplastic thyroid carcinoma. She underwent hemithyroidectomy and lymph node dissection of the central compartment. She remained in good health for 18 months after surgery. Anaplastic thyroid carcinoma is generally found as an aggressive large tumor, and the ultrasound appearance of small anaplastic thyroid carcinoma is poorly understood at present. We successfully detected anaplastic transformation in the early period by ultrasonography and FNA. When observation is indicated for small papillary thyroid carcinoma, the change in the shape of the nodule as well as in its diameter should be carefully monitored by ultrasonography. FNA should be performed at a proper site on the nodule to avoid overlooking anaplastic transformation, as resection following the early detection of anaplastic transformation might bring a favorable prognosis.https://www.jstage.jst.go.jp/article/endocrj/70/11/70_EJ23-0197/_html/-char/enpapillary microcarcinomaanaplastic thyroid carcinomaultrasonographyfine-needle aspiration cytology |
| spellingShingle | Hiroshi Arimitsu Yui Nishijima Naoyuki Higaki Hitoshi Noguchi Shinya Uchino Tsukasa Murakami A case report of anaplastic thyroid carcinoma transformed from small papillary carcinoma successfully detected by ultrasonography in its early stage with review of literature Endocrine Journal papillary microcarcinoma anaplastic thyroid carcinoma ultrasonography fine-needle aspiration cytology |
| title | A case report of anaplastic thyroid carcinoma transformed from small papillary carcinoma successfully detected by ultrasonography in its early stage with review of literature |
| title_full | A case report of anaplastic thyroid carcinoma transformed from small papillary carcinoma successfully detected by ultrasonography in its early stage with review of literature |
| title_fullStr | A case report of anaplastic thyroid carcinoma transformed from small papillary carcinoma successfully detected by ultrasonography in its early stage with review of literature |
| title_full_unstemmed | A case report of anaplastic thyroid carcinoma transformed from small papillary carcinoma successfully detected by ultrasonography in its early stage with review of literature |
| title_short | A case report of anaplastic thyroid carcinoma transformed from small papillary carcinoma successfully detected by ultrasonography in its early stage with review of literature |
| title_sort | case report of anaplastic thyroid carcinoma transformed from small papillary carcinoma successfully detected by ultrasonography in its early stage with review of literature |
| topic | papillary microcarcinoma anaplastic thyroid carcinoma ultrasonography fine-needle aspiration cytology |
| url | https://www.jstage.jst.go.jp/article/endocrj/70/11/70_EJ23-0197/_html/-char/en |
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