HIF factors cooperate with PML‐RARα to promote acute promyelocytic leukemia progression and relapse

HIF factors cooperate with PML‐RARα to promote acute promyelocytic leukemia progression and relapse

Abstract Acute promyelocytic leukemia (APL) is epitomized by the chromosomal translocation t(15;17) and the resulting oncogenic fusion protein PML‐RARα. Although acting primarily as a transcriptional repressor, PML‐RARα can also exert functions of transcriptional co‐activation. Here, we find that PM...

Full description

Saved in:
Bibliographic Details
Main Authors: Nadia Coltella, Stefano Percio, Roberta Valsecchi, Roberto Cuttano, Jlenia Guarnerio, Maurilio Ponzoni, Pier Paolo Pandolfi, Giovanni Melillo, Linda Pattini, Rosa Bernardi
Format: Article
Language:English
Published: Springer Nature 2014-04-01
Series:EMBO Molecular Medicine
Subjects:
acute promyelocytic leukemia
hypoxia‐inducible transcription factor
leukemia‐initiating cells
mouse models
PML‐RARα
Online Access:https://doi.org/10.1002/emmm.201303065
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1002/emmm.201303065

Similar Items