Mitochondria-derived reactive oxygen species induce over-differentiation of neural stem/progenitor cells after non-cytotoxic cisplatin exposure

Mitochondria-derived reactive oxygen species induce over-differentiation of neural stem/progenitor cells after non-cytotoxic cisplatin exposure

BackgroundNeural stem and progenitor cells (NSPCs) are crucial for nervous system development and self-renewal. However, their properties are sensitive to environmental and chemical factors, including chemotherapy agents like cisplatin, an FDA-approved drug used to treat cancer. Cisplatin inhibits D...

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Main Authors: Felipe A. Bustamante-Barrientos, Eliana Lara-Barba, Yeimi Herrera-Luna, Cynthia García-Guerrero, Eduardo Silva-Pavez, Jonathan Morales-Reyes, María Jesús Araya, Liliana Yanten-Fuentes, Noymar Luque-Campos, Claudia Altamirano, Ana María Vega-Letter, Patricia Luz-Crawford
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cysplatin
neural stem progenitor cells
mitochondrial ROS
oxidative stress
neurogenesis
stem cell differentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1555153/full
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https://www.frontiersin.org/articles/10.3389/fcell.2025.1555153/full

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