Potato protease inhibitors, a functional food material with antioxidant and anticancer potential
Potato protease inhibitors (PPIs), as the main component of potato protein isolate, have good safety, nutrition and great market potential. The antioxidant and anticancer properties of PPIs were evaluated with cell-based biological assays. The results showed that when the concentration of PPIs was 5...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2023-09-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023000277 |
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| author | Yaotong Liu Yuanyuan Bian Yan Bai Siqi Yu Yuxuan Tian Jie Li Suhong Li Tuoping Li |
| author_facet | Yaotong Liu Yuanyuan Bian Yan Bai Siqi Yu Yuxuan Tian Jie Li Suhong Li Tuoping Li |
| author_sort | Yaotong Liu |
| collection | DOAJ |
| description | Potato protease inhibitors (PPIs), as the main component of potato protein isolate, have good safety, nutrition and great market potential. The antioxidant and anticancer properties of PPIs were evaluated with cell-based biological assays. The results showed that when the concentration of PPIs was 5 mg/mL, the peroxyl radical scavenging value was (2119 ± 204) mg VCE/100 g, and the cellular antioxidant activity values were (45.83 ± 3.5) (no PBS wash) and (33.25 ± 4.4) µmol QE/100 g (PBS wash). Cells pretreated with PPIs could significantly prevent the oxidative damage induced by H2O2, inhibit the morphological changes of cells and maintain the integrity. Furthermore, PPIs had selective anti-proliferative effects on GIST882 cells (IC50 = (10.53 ± 3.87) mg/mL) and demonstrated potent inhibition of the growth, migration and invasion of cancer cells. These findings provide a scientific basis for PPIs as promising candidates for functional foods to aid in the prevention of oxidative damage and cancer. |
| format | Article |
| id | doaj-art-319841a1689f46afa819e74a91cff8a5 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-319841a1689f46afa819e74a91cff8a52025-02-03T05:40:26ZengTsinghua University PressFood Science and Human Wellness2213-45302023-09-0112517621771Potato protease inhibitors, a functional food material with antioxidant and anticancer potentialYaotong Liu0Yuanyuan Bian1Yan Bai2Siqi Yu3Yuxuan Tian4Jie Li5Suhong Li6Tuoping Li7College of Food Science, Shenyang Agricultural University, Shenyang 110866, ChinaCollege of Food Science, Shenyang Agricultural University, Shenyang 110866, ChinaCollege of Grain Science and Technology, Shenyang Normal University, Shenyang 110034, ChinaCollege of Food Science, Shenyang Agricultural University, Shenyang 110866, ChinaCollege of Food Science, Shenyang Agricultural University, Shenyang 110866, ChinaCollege of Pharmaceutical Science, Liaoning University, Shenyang 110036, ChinaCollege of Food Science, Shenyang Agricultural University, Shenyang 110866, China; Corresponding author at: College of Food Science, Shenyang Agricultural University, Shenyang 110866, China.College of Food Science, Shenyang Agricultural University, Shenyang 110866, China; Corresponding author at: College of Food Science, Shenyang Agricultural University, Shenyang 110866, China.Potato protease inhibitors (PPIs), as the main component of potato protein isolate, have good safety, nutrition and great market potential. The antioxidant and anticancer properties of PPIs were evaluated with cell-based biological assays. The results showed that when the concentration of PPIs was 5 mg/mL, the peroxyl radical scavenging value was (2119 ± 204) mg VCE/100 g, and the cellular antioxidant activity values were (45.83 ± 3.5) (no PBS wash) and (33.25 ± 4.4) µmol QE/100 g (PBS wash). Cells pretreated with PPIs could significantly prevent the oxidative damage induced by H2O2, inhibit the morphological changes of cells and maintain the integrity. Furthermore, PPIs had selective anti-proliferative effects on GIST882 cells (IC50 = (10.53 ± 3.87) mg/mL) and demonstrated potent inhibition of the growth, migration and invasion of cancer cells. These findings provide a scientific basis for PPIs as promising candidates for functional foods to aid in the prevention of oxidative damage and cancer.http://www.sciencedirect.com/science/article/pii/S2213453023000277Potato protease inhibitorsAntioxidant activityCytoprotectionAnticancer activity |
| spellingShingle | Yaotong Liu Yuanyuan Bian Yan Bai Siqi Yu Yuxuan Tian Jie Li Suhong Li Tuoping Li Potato protease inhibitors, a functional food material with antioxidant and anticancer potential Food Science and Human Wellness Potato protease inhibitors Antioxidant activity Cytoprotection Anticancer activity |
| title | Potato protease inhibitors, a functional food material with antioxidant and anticancer potential |
| title_full | Potato protease inhibitors, a functional food material with antioxidant and anticancer potential |
| title_fullStr | Potato protease inhibitors, a functional food material with antioxidant and anticancer potential |
| title_full_unstemmed | Potato protease inhibitors, a functional food material with antioxidant and anticancer potential |
| title_short | Potato protease inhibitors, a functional food material with antioxidant and anticancer potential |
| title_sort | potato protease inhibitors a functional food material with antioxidant and anticancer potential |
| topic | Potato protease inhibitors Antioxidant activity Cytoprotection Anticancer activity |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023000277 |
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