Glucagon like peptide-1 modulates urinary sodium excretion in diabetic kidney disease via ENaC activation

Glucagon like peptide-1 modulates urinary sodium excretion in diabetic kidney disease via ENaC activation

Abstract Diabetic kidney disease (DKD) is a leading cause of end stage kidney disease. Elevated salt sensitivity by epithelial sodium channel (ENaC) overexpression may be a residual risk factor for DKD. We found that combination therapy of linagliptin (LINA) to empagliflozin (EMPA), but not EMPA alo...

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Main Authors: Goh Kodama, Kensei Taguchi, Sakuya Ito, Yuri Nishino, Kayo Mori, Satomi Taguchi, Yuta Mitsuishi, Yuya Yamashita, Sho-ichi Yamagishi, Kei Fukami
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
GLP-1
GLP-1 receptor
DPP4 inhibitors
Diabetic kidney disease
SGLT2 inhibitors
Online Access:https://doi.org/10.1038/s41598-025-95673-9
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https://doi.org/10.1038/s41598-025-95673-9

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