Biofabrication of brain-like living tissue: structure to intelligence
Brain, the material foundation of human intelligence, is the most complex tissue in the human body. Brain diseases are among the leading threats to human life, yet our understanding of their pathogenic mechanisms and drug development remains limited, largely due to the lack of accurate brain-like ti...
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| Format: | Article |
| Language: | English |
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IOP Publishing
2025-01-01
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| Series: | International Journal of Extreme Manufacturing |
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| Online Access: | https://doi.org/10.1088/2631-7990/ada7a8 |
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| author | Ling Wang Sen Wang Yingjie Liu Bowen Zhang Zhaoyu Pan Luge Bai Siqi Yao Chenrui Zhang Huangfan Xie Jiankang He Dichen Li |
| author_facet | Ling Wang Sen Wang Yingjie Liu Bowen Zhang Zhaoyu Pan Luge Bai Siqi Yao Chenrui Zhang Huangfan Xie Jiankang He Dichen Li |
| author_sort | Ling Wang |
| collection | DOAJ |
| description | Brain, the material foundation of human intelligence, is the most complex tissue in the human body. Brain diseases are among the leading threats to human life, yet our understanding of their pathogenic mechanisms and drug development remains limited, largely due to the lack of accurate brain-like tissue models that replicate its complex structure and functions. Therefore, constructing brain-like models—both in morphology and function—possesses significant scientific value for advancing brain science and pathological pharmacology research, representing the frontiers in the biomanufacturing field. This review outlines the primary requirements and challenges in biomanufacturing brain-like tissue, addressing its complex structures, functions, and environments. Also, the existing biomanufacturing technologies, strategies, and characteristics for brain-like models are depicted, and cutting-edge developments in biomanufacturing central neural repair prosthetics, brain development models, brain disease models, and brain-inspired biocomputing models are systematically reviewed. Finally, the paper concludes with future perspectives on the biomanufacturing of brain-like tissue transitioning from structural manufacturing to intelligent functioning. |
| format | Article |
| id | doaj-art-3187de367151431f8c6ced0d2b7ccbc3 |
| institution | Kabale University |
| issn | 2631-7990 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | International Journal of Extreme Manufacturing |
| spelling | doaj-art-3187de367151431f8c6ced0d2b7ccbc32025-01-30T13:23:03ZengIOP PublishingInternational Journal of Extreme Manufacturing2631-79902025-01-017303200510.1088/2631-7990/ada7a8Biofabrication of brain-like living tissue: structure to intelligenceLing Wang0https://orcid.org/0000-0001-5897-8122Sen Wang1https://orcid.org/0000-0002-0593-2902Yingjie Liu2Bowen Zhang3Zhaoyu Pan4Luge Bai5Siqi Yao6Chenrui Zhang7Huangfan Xie8Jiankang He9https://orcid.org/0000-0002-9386-5833Dichen Li10State Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of China; National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of China; National Innovation Platform (Center) for Industry-Education Integration of Medical Technology, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of ChinaState Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of China; National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of China; National Innovation Platform (Center) for Industry-Education Integration of Medical Technology, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of ChinaState Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of China; National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of China; National Innovation Platform (Center) for Industry-Education Integration of Medical Technology, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of ChinaState Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of China; National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of China; National Innovation Platform (Center) for Industry-Education Integration of Medical Technology, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of ChinaState Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of China; National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of China; National Innovation Platform (Center) for Industry-Education Integration of Medical Technology, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of ChinaState Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of China; National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of China; National Innovation Platform (Center) for Industry-Education Integration of Medical Technology, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of ChinaState Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of China; National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of China; National Innovation Platform (Center) for Industry-Education Integration of Medical Technology, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of ChinaState Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of China; National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of China; National Innovation Platform (Center) for Industry-Education Integration of Medical Technology, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of ChinaLaboratory of Neurological Diseases and Brain Function, The Affiliated Hospital, Southwest Medical University , Luzhou 646000, People’s Republic of China; Institute of Epigenetics and Brain Science, Southwest Medical University , Luzhou 646000, People’s Republic of ChinaState Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of China; National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of China; National Innovation Platform (Center) for Industry-Education Integration of Medical Technology, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of ChinaState Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of China; National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of China; National Innovation Platform (Center) for Industry-Education Integration of Medical Technology, Xi’an Jiaotong University , Xi’an 710054, People’s Republic of ChinaBrain, the material foundation of human intelligence, is the most complex tissue in the human body. Brain diseases are among the leading threats to human life, yet our understanding of their pathogenic mechanisms and drug development remains limited, largely due to the lack of accurate brain-like tissue models that replicate its complex structure and functions. Therefore, constructing brain-like models—both in morphology and function—possesses significant scientific value for advancing brain science and pathological pharmacology research, representing the frontiers in the biomanufacturing field. This review outlines the primary requirements and challenges in biomanufacturing brain-like tissue, addressing its complex structures, functions, and environments. Also, the existing biomanufacturing technologies, strategies, and characteristics for brain-like models are depicted, and cutting-edge developments in biomanufacturing central neural repair prosthetics, brain development models, brain disease models, and brain-inspired biocomputing models are systematically reviewed. Finally, the paper concludes with future perspectives on the biomanufacturing of brain-like tissue transitioning from structural manufacturing to intelligent functioning.https://doi.org/10.1088/2631-7990/ada7a8biofabricationbrain-like tissuemulticellular printingnerve repair prosthesesbrain-inspired biocomputingpharmacopathological models |
| spellingShingle | Ling Wang Sen Wang Yingjie Liu Bowen Zhang Zhaoyu Pan Luge Bai Siqi Yao Chenrui Zhang Huangfan Xie Jiankang He Dichen Li Biofabrication of brain-like living tissue: structure to intelligence International Journal of Extreme Manufacturing biofabrication brain-like tissue multicellular printing nerve repair prostheses brain-inspired biocomputing pharmacopathological models |
| title | Biofabrication of brain-like living tissue: structure to intelligence |
| title_full | Biofabrication of brain-like living tissue: structure to intelligence |
| title_fullStr | Biofabrication of brain-like living tissue: structure to intelligence |
| title_full_unstemmed | Biofabrication of brain-like living tissue: structure to intelligence |
| title_short | Biofabrication of brain-like living tissue: structure to intelligence |
| title_sort | biofabrication of brain like living tissue structure to intelligence |
| topic | biofabrication brain-like tissue multicellular printing nerve repair prostheses brain-inspired biocomputing pharmacopathological models |
| url | https://doi.org/10.1088/2631-7990/ada7a8 |
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