Circulating Tissue Inhibitor of Matrix Metalloproteinase-4 (TIMP-4) in Systemic Sclerosis Patients with Elevated Pulmonary Arterial Pressure
Decreased levels of matrix metalloproteinases (MMPs) or excess levels of their tissue inhibitors (TIMPs) may contribute to dysregulation of extracellular matrix turnover in systemic sclerosis (SSc). In a cross-sectional study of 106 SSc patients, we measured serum levels of TIMP-4 which is preferen...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2008/164134 |
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| author | Gialafos J. Elias Moyssakis Ioannis Psaltopoulou Theodora Papadopoulos P. Dimitrios Perea Despoina Vlasis Kostantinos Kostopoulos Charalampos Votteas Vassilios Sfikakis P. Petros |
| author_facet | Gialafos J. Elias Moyssakis Ioannis Psaltopoulou Theodora Papadopoulos P. Dimitrios Perea Despoina Vlasis Kostantinos Kostopoulos Charalampos Votteas Vassilios Sfikakis P. Petros |
| author_sort | Gialafos J. Elias |
| collection | DOAJ |
| description | Decreased levels of matrix metalloproteinases (MMPs) or excess levels of their tissue inhibitors (TIMPs) may contribute to dysregulation of extracellular matrix turnover in systemic sclerosis (SSc). In a cross-sectional study of 106 SSc patients, we measured serum levels of TIMP-4 which is preferentially expressed in cardiovascular structures and searched for correlations with simultaneously performed echocardiography measurements of pulmonary artery systolic pressure (PASP), myocardial performance, and pulmonary function tests. TIMP-4, but not MMP-9, levels were significantly raised in patients with SSc than controls. However, in the subgroup of patients with PASP measurements lower to 40 mmHg (n=69), TIMP-4 levels were comparable to controls irrespective of the presence of diffuse or limited skin involvement, or lung fibrosis. Individual PASP measurements suggestive of pulmonary hypertension were associated with increased TIMP-4 serum levels (P=.03), independently of age, extent of skin sclerosis, or lung fibrosis, suggesting a cardiopulmonary vasculature-specific role of TIMP-4 activation in SSc. |
| format | Article |
| id | doaj-art-31875ec7ba5e4cc190a6cba9ca7a3362 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-31875ec7ba5e4cc190a6cba9ca7a33622025-02-03T05:44:32ZengWileyMediators of Inflammation0962-93511466-18612008-01-01200810.1155/2008/164134164134Circulating Tissue Inhibitor of Matrix Metalloproteinase-4 (TIMP-4) in Systemic Sclerosis Patients with Elevated Pulmonary Arterial PressureGialafos J. Elias0Moyssakis Ioannis1Psaltopoulou Theodora2Papadopoulos P. Dimitrios3Perea Despoina4Vlasis Kostantinos5Kostopoulos Charalampos6Votteas Vassilios7Sfikakis P. Petros8Cardiology Department, Laikon General Hospital, University of Athens Medical School, 115 27 Athens, GreeceCardiology Department, Laikon General Hospital, University of Athens Medical School, 115 27 Athens, GreeceDepartment of Hygiene and Epidemiology, University of Athens Medical School, 115 27 Athens, GreeceCardiology Department, Laikon General Hospital, University of Athens Medical School, 115 27 Athens, GreeceFirst Department of Propaedeutic and Internal Medicine, University of Athens Medical School, 115 27 Athens, GreeceFirst Department of Propaedeutic and Internal Medicine, University of Athens Medical School, 115 27 Athens, GreecePulmonary Unit, Department of Therapeutics, University of Athens Medical School, 115 27 Athens, GreeceCardiology Department, Laikon General Hospital, University of Athens Medical School, 115 27 Athens, GreeceFirst Department of Propaedeutic and Internal Medicine, University of Athens Medical School, 115 27 Athens, GreeceDecreased levels of matrix metalloproteinases (MMPs) or excess levels of their tissue inhibitors (TIMPs) may contribute to dysregulation of extracellular matrix turnover in systemic sclerosis (SSc). In a cross-sectional study of 106 SSc patients, we measured serum levels of TIMP-4 which is preferentially expressed in cardiovascular structures and searched for correlations with simultaneously performed echocardiography measurements of pulmonary artery systolic pressure (PASP), myocardial performance, and pulmonary function tests. TIMP-4, but not MMP-9, levels were significantly raised in patients with SSc than controls. However, in the subgroup of patients with PASP measurements lower to 40 mmHg (n=69), TIMP-4 levels were comparable to controls irrespective of the presence of diffuse or limited skin involvement, or lung fibrosis. Individual PASP measurements suggestive of pulmonary hypertension were associated with increased TIMP-4 serum levels (P=.03), independently of age, extent of skin sclerosis, or lung fibrosis, suggesting a cardiopulmonary vasculature-specific role of TIMP-4 activation in SSc.http://dx.doi.org/10.1155/2008/164134 |
| spellingShingle | Gialafos J. Elias Moyssakis Ioannis Psaltopoulou Theodora Papadopoulos P. Dimitrios Perea Despoina Vlasis Kostantinos Kostopoulos Charalampos Votteas Vassilios Sfikakis P. Petros Circulating Tissue Inhibitor of Matrix Metalloproteinase-4 (TIMP-4) in Systemic Sclerosis Patients with Elevated Pulmonary Arterial Pressure Mediators of Inflammation |
| title | Circulating Tissue Inhibitor of Matrix Metalloproteinase-4 (TIMP-4) in Systemic Sclerosis Patients with Elevated Pulmonary Arterial Pressure |
| title_full | Circulating Tissue Inhibitor of Matrix Metalloproteinase-4 (TIMP-4) in Systemic Sclerosis Patients with Elevated Pulmonary Arterial Pressure |
| title_fullStr | Circulating Tissue Inhibitor of Matrix Metalloproteinase-4 (TIMP-4) in Systemic Sclerosis Patients with Elevated Pulmonary Arterial Pressure |
| title_full_unstemmed | Circulating Tissue Inhibitor of Matrix Metalloproteinase-4 (TIMP-4) in Systemic Sclerosis Patients with Elevated Pulmonary Arterial Pressure |
| title_short | Circulating Tissue Inhibitor of Matrix Metalloproteinase-4 (TIMP-4) in Systemic Sclerosis Patients with Elevated Pulmonary Arterial Pressure |
| title_sort | circulating tissue inhibitor of matrix metalloproteinase 4 timp 4 in systemic sclerosis patients with elevated pulmonary arterial pressure |
| url | http://dx.doi.org/10.1155/2008/164134 |
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