Gelsolin (GSN) as a key regulator in estrogen receptor-positive breast cancer: implications for prognosis, chemotherapy sensitivity, and immune infiltration

Gelsolin (GSN) as a key regulator in estrogen receptor-positive breast cancer: implications for prognosis, chemotherapy sensitivity, and immune infiltration

Abstract Background Gelsolin (GSN), a cytoskeletal regulatory protein implicated in cancer progression, remains understudied in estrogen receptor-positive breast cancer (ER + BC), particularly regarding its links to immune infiltration and drug resistance. Methods: Transcriptomic data from TCGA (616...

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Bibliographic Details
Main Authors: Mian Lv, Huiling Wang, Guanqing Feng, Qingxiao Nong, Shouwen Tao, Yanfei Ma, Dalang Fang
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Discover Oncology
Subjects:
Gelsolin (GSN)
Estrogen receptor-positive breast cancer
Immune infiltration
Chemotherapy sensitivity
Mendelian randomization
Online Access:https://doi.org/10.1007/s12672-025-03128-4
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https://doi.org/10.1007/s12672-025-03128-4

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