Sirt2 Regulates Liver Metabolism in a Sex-Specific Manner

Sirtuin-2 (Sirt2), an NAD+-dependent lysine deacylase enzyme, has previously been implicated as a regulator of glucose metabolism, but the specific mechanisms remain poorly defined. Here, we observed that <i>Sirt2−/−</i> males, but not females, have decreased body fat, moderate hypoglyce...

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Bibliographic Details
Main Authors: Alexandra V. Schmidt, Sivakama S. Bharathi, Keaton J. Solo, Joanna Bons, Jacob P. Rose, Birgit Schilling, Eric S. Goetzman
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Biomolecules
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Online Access:https://www.mdpi.com/2218-273X/14/9/1160
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