Use of Recombinant Antigens for the Diagnosis of Invasive Candidiasis
Invasive candidiasis is a frequent and often fatal complication in immunocompromised and critically ill patients. Unfortunately, the diagnosis of invasive candidiasis remains difficult due to the lack of specific clinical symptoms and a definitive diagnostic method. The detection of antibodies again...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2008/721950 |
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| author | Ana Laín Natalia Elguezabal Elena Amutio Iñigo Fernández de Larrinoa María Dolores Moragues José Pontón |
| author_facet | Ana Laín Natalia Elguezabal Elena Amutio Iñigo Fernández de Larrinoa María Dolores Moragues José Pontón |
| author_sort | Ana Laín |
| collection | DOAJ |
| description | Invasive candidiasis is a frequent and often fatal complication in immunocompromised and critically ill patients. Unfortunately, the diagnosis of invasive candidiasis remains difficult due to the lack of specific clinical symptoms and a definitive diagnostic method. The detection of antibodies against different Candida antigens may help in the diagnosis. However, the methods traditionally used for the detection of antibodies have been based on crude antigenic fungal extracts, which usually show low-reproducibility and cross-reactivity problems. The development of molecular biology techniques has allowed the production of recombinant antigens which may help to solve these problems. In this review we will discuss the usefulness of recombinant antigens in the diagnosis of invasive candidiasis. |
| format | Article |
| id | doaj-art-310ff8dad1f64f708e6286b6722e1fa9 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-310ff8dad1f64f708e6286b6722e1fa92025-02-03T01:30:10ZengWileyClinical and Developmental Immunology1740-25221740-25302008-01-01200810.1155/2008/721950721950Use of Recombinant Antigens for the Diagnosis of Invasive CandidiasisAna Laín0Natalia Elguezabal1Elena Amutio2Iñigo Fernández de Larrinoa3María Dolores Moragues4José Pontón5Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Odontología, Universidad del País Vasco, Apartado 699, 48080 Bilbao, Vizcaya, SpainDepartamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Odontología, Universidad del País Vasco, Apartado 699, 48080 Bilbao, Vizcaya, SpainDepartamento de Enfermería I, Universidad del País Vasco, Barrio Sarriena s/n, 48940 Lejona, Vizcaya, SpainServicio de Hematología, Hospital de Cruces, Plaza de Cruces s/n, 48903 Cruces, Barakaldo, SpainDepartamento de Química Aplicada, Facultad de Química, Universidad del País Vasco, Paseo de Manuel de Lardizabal y Uribe n°3, 20018 San Sebastián, Gipuzkoa, SpainDepartamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Odontología, Universidad del País Vasco, Apartado 699, 48080 Bilbao, Vizcaya, SpainInvasive candidiasis is a frequent and often fatal complication in immunocompromised and critically ill patients. Unfortunately, the diagnosis of invasive candidiasis remains difficult due to the lack of specific clinical symptoms and a definitive diagnostic method. The detection of antibodies against different Candida antigens may help in the diagnosis. However, the methods traditionally used for the detection of antibodies have been based on crude antigenic fungal extracts, which usually show low-reproducibility and cross-reactivity problems. The development of molecular biology techniques has allowed the production of recombinant antigens which may help to solve these problems. In this review we will discuss the usefulness of recombinant antigens in the diagnosis of invasive candidiasis.http://dx.doi.org/10.1155/2008/721950 |
| spellingShingle | Ana Laín Natalia Elguezabal Elena Amutio Iñigo Fernández de Larrinoa María Dolores Moragues José Pontón Use of Recombinant Antigens for the Diagnosis of Invasive Candidiasis Clinical and Developmental Immunology |
| title | Use of Recombinant Antigens for the Diagnosis of Invasive Candidiasis |
| title_full | Use of Recombinant Antigens for the Diagnosis of Invasive Candidiasis |
| title_fullStr | Use of Recombinant Antigens for the Diagnosis of Invasive Candidiasis |
| title_full_unstemmed | Use of Recombinant Antigens for the Diagnosis of Invasive Candidiasis |
| title_short | Use of Recombinant Antigens for the Diagnosis of Invasive Candidiasis |
| title_sort | use of recombinant antigens for the diagnosis of invasive candidiasis |
| url | http://dx.doi.org/10.1155/2008/721950 |
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