Old Age Exacerbates White Matter Neuroinflammation and Cognitive Deficits Following Closed-Head Injury, Particularly in Female Mice

Old Age Exacerbates White Matter Neuroinflammation and Cognitive Deficits Following Closed-Head Injury, Particularly in Female Mice

The increasing incidence of traumatic brain injury (TBI) among older adults, particularly mild injuries from falls, underscores the need to investigate age-related outcomes and potential sex differences in response to TBI. Although previous research has defined an aging-TBI signature (heightened gli...

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Bibliographic Details
Main Authors: Teresa Macheda, Margaret R. Andres, Lydia Sanders, Kelly N. Roberts, Ryan K. Shahidehpour, Josh M. Morganti, Adam D. Bachstetter
Format: Article
Language:English
Published: Mary Ann Liebert 2024-11-01
Series:Neurotrauma Reports
Subjects:
aging
astrocytes
brain injury
microglia
neuroinflammation
sex differences
Online Access:https://www.liebertpub.com/doi/10.1089/neur.2024.0074
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