Recent advancements to enhance the therapeutic efficacy of antiepileptic drugs
Epilepsy is a multifactorial neurological disorder characterized by recurrent or unprovoked seizures. Over the past two decades, many new antiepileptic drugs (AEDs) were developed and are in use for the treatment of epilepsy. However, drug resistance, drug-drug interaction and adverse events are com...
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2021-12-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2021-0041 |
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| author | Li Fuquan Singh Akhilesh Vikram |
| author_facet | Li Fuquan Singh Akhilesh Vikram |
| author_sort | Li Fuquan |
| collection | DOAJ |
| description | Epilepsy is a multifactorial neurological disorder characterized by recurrent or unprovoked seizures. Over the past two decades, many new antiepileptic drugs (AEDs) were developed and are in use for the treatment of epilepsy. However, drug resistance, drug-drug interaction and adverse events are common problems associated with AEDs. Antiepileptic drugs must be used only if the ratio of efficacy, safety, and tolerability of treatment are favorable and outweigh the disadvantages including treatment costs. The application of novel drug delivery techniques could enhance the efficacy and reduce the toxicity of AEDs. These novel techniques aim to deliver an optimal concentration of the drug more specifically to the seizure focus or foci in the CNS without numerous side-effects. The purpose of this article is to review the recent advancements in antiepileptic treatment and summarize the novel modalities in the route of administration and drug delivery, including gene therapy, for effective treatment of epilepsy. |
| format | Article |
| id | doaj-art-30fb64894cef4908a06857999d94e6ed |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-30fb64894cef4908a06857999d94e6ed2025-02-02T15:38:24ZengSciendoActa Pharmaceutica1846-95582021-12-0171452754410.2478/acph-2021-0041Recent advancements to enhance the therapeutic efficacy of antiepileptic drugsLi Fuquan0Singh Akhilesh Vikram1Zhangqiu District Maternal and Child Health Hospital, Jinan City, Shandong Province, ChinaSchool of Epidemiology and Public Health, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, IndiaEpilepsy is a multifactorial neurological disorder characterized by recurrent or unprovoked seizures. Over the past two decades, many new antiepileptic drugs (AEDs) were developed and are in use for the treatment of epilepsy. However, drug resistance, drug-drug interaction and adverse events are common problems associated with AEDs. Antiepileptic drugs must be used only if the ratio of efficacy, safety, and tolerability of treatment are favorable and outweigh the disadvantages including treatment costs. The application of novel drug delivery techniques could enhance the efficacy and reduce the toxicity of AEDs. These novel techniques aim to deliver an optimal concentration of the drug more specifically to the seizure focus or foci in the CNS without numerous side-effects. The purpose of this article is to review the recent advancements in antiepileptic treatment and summarize the novel modalities in the route of administration and drug delivery, including gene therapy, for effective treatment of epilepsy.https://doi.org/10.2478/acph-2021-0041antiepileptic drugsdrug deliveryepilepsygene therapyliposomesnanoparticles |
| spellingShingle | Li Fuquan Singh Akhilesh Vikram Recent advancements to enhance the therapeutic efficacy of antiepileptic drugs Acta Pharmaceutica antiepileptic drugs drug delivery epilepsy gene therapy liposomes nanoparticles |
| title | Recent advancements to enhance the therapeutic efficacy of antiepileptic drugs |
| title_full | Recent advancements to enhance the therapeutic efficacy of antiepileptic drugs |
| title_fullStr | Recent advancements to enhance the therapeutic efficacy of antiepileptic drugs |
| title_full_unstemmed | Recent advancements to enhance the therapeutic efficacy of antiepileptic drugs |
| title_short | Recent advancements to enhance the therapeutic efficacy of antiepileptic drugs |
| title_sort | recent advancements to enhance the therapeutic efficacy of antiepileptic drugs |
| topic | antiepileptic drugs drug delivery epilepsy gene therapy liposomes nanoparticles |
| url | https://doi.org/10.2478/acph-2021-0041 |
| work_keys_str_mv | AT lifuquan recentadvancementstoenhancethetherapeuticefficacyofantiepilepticdrugs AT singhakhileshvikram recentadvancementstoenhancethetherapeuticefficacyofantiepilepticdrugs |