The autoimmune disease risk variant NCF1-His90 is associated with a reduced risk of tuberculosis in women

The autoimmune disease risk variant NCF1-His90 is associated with a reduced risk of tuberculosis in women

IntroductionThe neutrophil cytosolic factor 1 (NCF1) rs201802880 polymorphism is a missense mutation resulting in an amino acid substitution from arginine to histidine at position 90, which impairs the function of NADPH oxidase. This casual variant confers an increased risk for multiple autoimmune d...

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Bibliographic Details
Main Authors: Xinjun Hu, Shasha Li, Renliang Huang, Ziwei Fu, Chenyu Ma, Zheng Cheng, Hongjun Hu, Qiaomiao Zhou, Frank Petersen, Xinhua Yu, Junfeng Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
autoimmune diseases (AD)
infectious diseases
neutrophil cytosolic factor 1 (NCF1)
genetic association
evolutionary trade-offs
tuberculosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1514296/full
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