Nationwide multi-centric prospective study for the identification of biomarkers to predict the treatment responses of nivolumab through comprehensive analyses of pretreatment plasma exosome mRNAs from head and neck cancer patients (BIONEXT study)

Nationwide multi-centric prospective study for the identification of biomarkers to predict the treatment responses of nivolumab through comprehensive analyses of pretreatment plasma exosome mRNAs from head and neck cancer patients (BIONEXT study)

BackgroundNivolumab paved a new way in the treatment of patients with recurrent or metastatic (RM) head and neck squamous cell carcinoma (RM-HNSCC). However, the limited rates of long-term survivors (< 20%) demand a robust prognostic biomarker. This nationwide multi-centric prospective study...

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Main Authors: Kuniaki Sato, Satoshi Toh, Taku Murakami, Takafumi Nakano, Takahiro Hongo, Mioko Matsuo, Kazuki Hashimoto, Masashi Sugasawa, Keisuke Yamazaki, Yushi Ueki, Torahiko Nakashima, Hideoki Uryu, Takeharu Ono, Hirohito Umeno, Tsutomu Ueda, Satoshi Kano, Kiyoaki Tsukahara, Akihito Watanabe, Ichiro Ota, Nobuya Monden, Shigemichi Iwae, Takashi Maruo, Yukinori Asada, Nobuhiro Hanai, Daisuke Sano, Hiroyuki Ozawa, Takahiro Asakage, Takahito Fukusumi, Muneyuki Masuda
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
nivolumab
head and neck cancer
biomarker
exosome
HLA-E
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1464419/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1464419/full

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