Avelumab-Induced Scleroderma in a Patient with Metastatic Squamous Cell Carcinoma of the Lung
Immune checkpoint inhibitors are associated with a spectrum of cutaneous immune-related adverse events. While maculopapular eruptions are the most common cutaneous adverse event, scleroderma can rarely develop. Herein, we report a case of new-onset scleroderma associated with avelumab treatment in t...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Dermatological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2022/5360113 |
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| author | Jeffrey L. Dobrzynski Blake E. Vest Brian L. Swick |
| author_facet | Jeffrey L. Dobrzynski Blake E. Vest Brian L. Swick |
| author_sort | Jeffrey L. Dobrzynski |
| collection | DOAJ |
| description | Immune checkpoint inhibitors are associated with a spectrum of cutaneous immune-related adverse events. While maculopapular eruptions are the most common cutaneous adverse event, scleroderma can rarely develop. Herein, we report a case of new-onset scleroderma associated with avelumab treatment in the setting of metastatic squamous cell carcinoma of the lung. The pathophysiology of immune checkpoint inhibitor-induced scleroderma is not completely understood. A proposed mechanism is discussed along with the clinical presentation of symptoms and associated therapeutic response in cancer treatment. This case contributes to the few existing reports of immune checkpoint inhibitor-induced scleroderma to better understand the implications in the management of cutaneous immune-related adverse events. |
| format | Article |
| id | doaj-art-30d76c09809e4ea5bd014529984b7c85 |
| institution | Kabale University |
| issn | 2090-6471 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dermatological Medicine |
| spelling | doaj-art-30d76c09809e4ea5bd014529984b7c852025-02-03T05:58:32ZengWileyCase Reports in Dermatological Medicine2090-64712022-01-01202210.1155/2022/5360113Avelumab-Induced Scleroderma in a Patient with Metastatic Squamous Cell Carcinoma of the LungJeffrey L. Dobrzynski0Blake E. Vest1Brian L. Swick2University of Iowa Roy J. and Lucille A. Carver College of MedicineUniversity of Iowa Hospitals and ClinicsUniversity of Iowa Hospitals and ClinicsImmune checkpoint inhibitors are associated with a spectrum of cutaneous immune-related adverse events. While maculopapular eruptions are the most common cutaneous adverse event, scleroderma can rarely develop. Herein, we report a case of new-onset scleroderma associated with avelumab treatment in the setting of metastatic squamous cell carcinoma of the lung. The pathophysiology of immune checkpoint inhibitor-induced scleroderma is not completely understood. A proposed mechanism is discussed along with the clinical presentation of symptoms and associated therapeutic response in cancer treatment. This case contributes to the few existing reports of immune checkpoint inhibitor-induced scleroderma to better understand the implications in the management of cutaneous immune-related adverse events.http://dx.doi.org/10.1155/2022/5360113 |
| spellingShingle | Jeffrey L. Dobrzynski Blake E. Vest Brian L. Swick Avelumab-Induced Scleroderma in a Patient with Metastatic Squamous Cell Carcinoma of the Lung Case Reports in Dermatological Medicine |
| title | Avelumab-Induced Scleroderma in a Patient with Metastatic Squamous Cell Carcinoma of the Lung |
| title_full | Avelumab-Induced Scleroderma in a Patient with Metastatic Squamous Cell Carcinoma of the Lung |
| title_fullStr | Avelumab-Induced Scleroderma in a Patient with Metastatic Squamous Cell Carcinoma of the Lung |
| title_full_unstemmed | Avelumab-Induced Scleroderma in a Patient with Metastatic Squamous Cell Carcinoma of the Lung |
| title_short | Avelumab-Induced Scleroderma in a Patient with Metastatic Squamous Cell Carcinoma of the Lung |
| title_sort | avelumab induced scleroderma in a patient with metastatic squamous cell carcinoma of the lung |
| url | http://dx.doi.org/10.1155/2022/5360113 |
| work_keys_str_mv | AT jeffreyldobrzynski avelumabinducedsclerodermainapatientwithmetastaticsquamouscellcarcinomaofthelung AT blakeevest avelumabinducedsclerodermainapatientwithmetastaticsquamouscellcarcinomaofthelung AT brianlswick avelumabinducedsclerodermainapatientwithmetastaticsquamouscellcarcinomaofthelung |