Sleep Disruption and Proprioceptive Delirium due to Acetaminophen in a Pediatric Patient
We present the case of a 7-year-old boy, who received acetaminophen for the treatment of hyperpyrexia, due to an infection of the superior airways. 13 mg/kg (260 mg) of acetaminophen was administered orally before bedtime, and together with the expected antipyretic effect, the boy experienced sleep...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2013/471294 |
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| author | Carla Carnovale Marco Pozzi Andrea Angelo Nisic Elisa Scrofani Valentina Perrone Stefania Antoniazzi Emilio Clementi Sonia Radice |
| author_facet | Carla Carnovale Marco Pozzi Andrea Angelo Nisic Elisa Scrofani Valentina Perrone Stefania Antoniazzi Emilio Clementi Sonia Radice |
| author_sort | Carla Carnovale |
| collection | DOAJ |
| description | We present the case of a 7-year-old boy, who received acetaminophen for the treatment of hyperpyrexia, due to an infection of the superior airways. 13 mg/kg (260 mg) of acetaminophen was administered orally before bedtime, and together with the expected antipyretic effect, the boy experienced sleep disruption and proprioceptive delirium. The symptoms disappeared within one hour. In the following six months, acetaminophen was administered again twice, and the reaction reappeared with similar features. Potential alternative explanations were excluded, and analysis with the Naranjo algorithm indicated a “probable” relationship between acetaminophen and this adverse reaction. We discuss the potential mechanisms involved, comprising imbalances in prostaglandin levels, alterations of dopamine, and cannabinoid and serotonin signalings. |
| format | Article |
| id | doaj-art-30d10fa148e4453d9b40e2af6b397536 |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-30d10fa148e4453d9b40e2af6b3975362025-02-03T01:22:37ZengWileyCase Reports in Pediatrics2090-68032090-68112013-01-01201310.1155/2013/471294471294Sleep Disruption and Proprioceptive Delirium due to Acetaminophen in a Pediatric PatientCarla Carnovale0Marco Pozzi1Andrea Angelo Nisic2Elisa Scrofani3Valentina Perrone4Stefania Antoniazzi5Emilio Clementi6Sonia Radice7Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, University Hospital “Luigi Sacco” Università di Milano, 20157 Milan, ItalyScientific Institute, IRCCS Eugenio Medea, 23842 Bosisio Parini, Lecco, ItalyPharmaceutical Service, Azienda Sanitaria Locale di Bergamo, 24100 Bergamo, ItalyFamily Pediatricians, Territorial Health Service of Bergamo, 24100 Bergamo, ItalyUnit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, University Hospital “Luigi Sacco” Università di Milano, 20157 Milan, ItalyUnit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, University Hospital “Luigi Sacco” Università di Milano, 20157 Milan, ItalyUnit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, University Hospital “Luigi Sacco” Università di Milano, 20157 Milan, ItalyUnit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, University Hospital “Luigi Sacco” Università di Milano, 20157 Milan, ItalyWe present the case of a 7-year-old boy, who received acetaminophen for the treatment of hyperpyrexia, due to an infection of the superior airways. 13 mg/kg (260 mg) of acetaminophen was administered orally before bedtime, and together with the expected antipyretic effect, the boy experienced sleep disruption and proprioceptive delirium. The symptoms disappeared within one hour. In the following six months, acetaminophen was administered again twice, and the reaction reappeared with similar features. Potential alternative explanations were excluded, and analysis with the Naranjo algorithm indicated a “probable” relationship between acetaminophen and this adverse reaction. We discuss the potential mechanisms involved, comprising imbalances in prostaglandin levels, alterations of dopamine, and cannabinoid and serotonin signalings.http://dx.doi.org/10.1155/2013/471294 |
| spellingShingle | Carla Carnovale Marco Pozzi Andrea Angelo Nisic Elisa Scrofani Valentina Perrone Stefania Antoniazzi Emilio Clementi Sonia Radice Sleep Disruption and Proprioceptive Delirium due to Acetaminophen in a Pediatric Patient Case Reports in Pediatrics |
| title | Sleep Disruption and Proprioceptive Delirium due to Acetaminophen in a Pediatric Patient |
| title_full | Sleep Disruption and Proprioceptive Delirium due to Acetaminophen in a Pediatric Patient |
| title_fullStr | Sleep Disruption and Proprioceptive Delirium due to Acetaminophen in a Pediatric Patient |
| title_full_unstemmed | Sleep Disruption and Proprioceptive Delirium due to Acetaminophen in a Pediatric Patient |
| title_short | Sleep Disruption and Proprioceptive Delirium due to Acetaminophen in a Pediatric Patient |
| title_sort | sleep disruption and proprioceptive delirium due to acetaminophen in a pediatric patient |
| url | http://dx.doi.org/10.1155/2013/471294 |
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