Hypoxia-Inducible Factor-1 as a Therapeutic Target in Endometrial Cancer Management

In the Western world, endometrial cancer (EC) is the most common malignant tumor of the female genital tract. Solid tumors like EC outgrow their vasculature resulting in hypoxia. Tumor hypoxia is important because it renders an aggressive phenotype and leads to radio- and chemo-therapy resistance. H...

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Bibliographic Details
Main Authors: Laura M. S. Seeber, Ronald P. Zweemer, René H. M. Verheijen, Paul J. van Diest
Format: Article
Language:English
Published: Wiley 2010-01-01
Series:Obstetrics and Gynecology International
Online Access:http://dx.doi.org/10.1155/2010/580971
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