Enhancing DNA Vaccine Delivery Through Stearyl-Modified Cell-Penetrating Peptides: Improved Antigen Expression and Immune Response In Vitro and In Vivo

Enhancing DNA Vaccine Delivery Through Stearyl-Modified Cell-Penetrating Peptides: Improved Antigen Expression and Immune Response In Vitro and In Vivo

Background: Inefficient cellular uptake is a significant limitation to the efficacy of DNA vaccines. In this study, we introduce S-Cr9T, a stearyl-modified cell-penetrating peptide (CPP) designed to enhance DNA vaccine delivery by forming stable complexes with plasmid DNA, thereby protecting it from...

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Bibliographic Details
Main Authors: Sheng Jiang, Cheng Zu, Bin Wang, Yiwei Zhong
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Vaccines
Subjects:
DNA vaccine
cell-penetrating peptide
in vitro expression
in vivo expression
antibody response
T cell response
Online Access:https://www.mdpi.com/2076-393X/13/1/94
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