MED13‐dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver

MED13‐dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver

Abstract The heart requires a continuous supply of energy but has little capacity for energy storage and thus relies on exogenous metabolic sources. We previously showed that cardiac MED13 modulates systemic energy homeostasis in mice. Here, we sought to define the extra‐cardiac tissue(s) that respo...

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Main Authors: Kedryn K Baskin, Chad E Grueter, Christine M Kusminski, William L Holland, Angie L Bookout, Santosh Satapati, Y Megan Kong, Shawn C Burgess, Craig R Malloy, Philipp E Scherer, Christopher B Newgard, Rhonda Bassel‐Duby, Eric N Olson
Format: Article
Language:English
Published: Springer Nature 2014-11-01
Series:EMBO Molecular Medicine
Subjects:
energy homeostasis
mediator complex
metabolic flexibility
metabolic gene expression
metabolism
Online Access:https://doi.org/10.15252/emmm.201404218
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https://doi.org/10.15252/emmm.201404218

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