Allele and genotype frequencies of variants in P450 cytochromes, transports, and DNA repair enzymes in the Dominican Republic population

Allele and genotype frequencies of variants in P450 cytochromes, transports, and DNA repair enzymes in the Dominican Republic population

IntroductionSingle-nucleotide variants (SNVs) give rise to important inter-individual and inter-ethnic variabilities in the metabolism and disposition of several therapeutic agents and may cause differences in the treatment response to clinically important drugs like antiarrhythmics, antidepressants...

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Main Authors: Elizabeth Pérez-Duval, Berniza Calderón, Marlen Izquierdo, José A. Herrera-Isidrón, Elizabeth Reyes-Reyes, Alejandro Herrera, Manuel Soto, Alba Beltré, Idania Rodeiro-Guerra
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
genetic variants
SNVs
pharmacogenetic
Dominic Republic population
admixed population
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1494482/full
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