Allele and genotype frequencies of variants in P450 cytochromes, transports, and DNA repair enzymes in the Dominican Republic population

IntroductionSingle-nucleotide variants (SNVs) give rise to important inter-individual and inter-ethnic variabilities in the metabolism and disposition of several therapeutic agents and may cause differences in the treatment response to clinically important drugs like antiarrhythmics, antidepressants...

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Main Authors: Elizabeth Pérez-Duval, Berniza Calderón, Marlen Izquierdo, José A. Herrera-Isidrón, Elizabeth Reyes-Reyes, Alejandro Herrera, Manuel Soto, Alba Beltré, Idania Rodeiro-Guerra
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
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Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1494482/full
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