The effect of AKT inhibition in α-synuclein-dependent neurodegeneration

The effect of AKT inhibition in α-synuclein-dependent neurodegeneration

Parkinson’s disease (PD) is a progressive neurodegenerative disorder affecting millions of individuals worldwide. A hallmark of PD pathology is the accumulation of α-synuclein (α-Syn), a small protein known to support neuronal development and function. However, in PD, α-Syn cumulatively misfolds int...

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Bibliographic Details
Main Authors:	Bedri Ranxhi, Zoya R. Bangash, Zachary M. Chbihi, Sokol V. Todi, Peter A. LeWitt, Wei-Ling Tsou
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-02-01
Series:	Frontiers in Molecular Neuroscience
Subjects:	α-synuclein synucleinopathy AKT NF-κB neurodegenerative disease Parkinson’s disease
Online Access:	https://www.frontiersin.org/articles/10.3389/fnmol.2025.1524044/full
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