Animal Models of Non-Respiratory, Post-Acute Sequelae of COVID-19
Post-acute sequelae of COVID-19 (PASC) are a diverse set of symptoms and syndromes driven by dysfunction of multiple organ systems that can persist for years and negatively impact the quality of life for millions of individuals. We currently lack specific therapeutics for patients with PASC, due in...
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| Format: | Article |
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MDPI AG
2025-01-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/17/1/98 |
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| author | Abigail Vanderheiden Michael S. Diamond |
| author_facet | Abigail Vanderheiden Michael S. Diamond |
| author_sort | Abigail Vanderheiden |
| collection | DOAJ |
| description | Post-acute sequelae of COVID-19 (PASC) are a diverse set of symptoms and syndromes driven by dysfunction of multiple organ systems that can persist for years and negatively impact the quality of life for millions of individuals. We currently lack specific therapeutics for patients with PASC, due in part to an incomplete understanding of its pathogenesis, especially for non-pulmonary sequelae. Here, we discuss three animal models that have been utilized to investigate PASC: non-human primates (NHPs), hamsters, and mice. We focus on neurological, gastrointestinal, and cardiovascular PASC and highlight advances in mechanistic insight that have been made using these animal models, as well as discussing the sequelae that warrant continued and intensive research. |
| format | Article |
| id | doaj-art-30a2aa2276104bf184a8c7c0914bc5db |
| institution | Kabale University |
| issn | 1999-4915 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-30a2aa2276104bf184a8c7c0914bc5db2025-01-24T13:52:35ZengMDPI AGViruses1999-49152025-01-011719810.3390/v17010098Animal Models of Non-Respiratory, Post-Acute Sequelae of COVID-19Abigail Vanderheiden0Michael S. Diamond1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USADepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USAPost-acute sequelae of COVID-19 (PASC) are a diverse set of symptoms and syndromes driven by dysfunction of multiple organ systems that can persist for years and negatively impact the quality of life for millions of individuals. We currently lack specific therapeutics for patients with PASC, due in part to an incomplete understanding of its pathogenesis, especially for non-pulmonary sequelae. Here, we discuss three animal models that have been utilized to investigate PASC: non-human primates (NHPs), hamsters, and mice. We focus on neurological, gastrointestinal, and cardiovascular PASC and highlight advances in mechanistic insight that have been made using these animal models, as well as discussing the sequelae that warrant continued and intensive research.https://www.mdpi.com/1999-4915/17/1/98coronaviruslong COVIDpathogenesismouse modelsbrainheart |
| spellingShingle | Abigail Vanderheiden Michael S. Diamond Animal Models of Non-Respiratory, Post-Acute Sequelae of COVID-19 Viruses coronavirus long COVID pathogenesis mouse models brain heart |
| title | Animal Models of Non-Respiratory, Post-Acute Sequelae of COVID-19 |
| title_full | Animal Models of Non-Respiratory, Post-Acute Sequelae of COVID-19 |
| title_fullStr | Animal Models of Non-Respiratory, Post-Acute Sequelae of COVID-19 |
| title_full_unstemmed | Animal Models of Non-Respiratory, Post-Acute Sequelae of COVID-19 |
| title_short | Animal Models of Non-Respiratory, Post-Acute Sequelae of COVID-19 |
| title_sort | animal models of non respiratory post acute sequelae of covid 19 |
| topic | coronavirus long COVID pathogenesis mouse models brain heart |
| url | https://www.mdpi.com/1999-4915/17/1/98 |
| work_keys_str_mv | AT abigailvanderheiden animalmodelsofnonrespiratorypostacutesequelaeofcovid19 AT michaelsdiamond animalmodelsofnonrespiratorypostacutesequelaeofcovid19 |