The alterations of molecular repertoire of the RANKL-induced osteoclastogenesis in the M1 macrophage-derived inflammatory milieu

Abstract Inflammation have been linked to bone diseases such as osteoporosis or bone destruction. However, whether M1 inflammatory stimuli exert a stimulatory or inhibitory effect on the differentiation of osteoclasts remained controversial. Also, how inflammatory milieu influence cell proliferation...

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Bibliographic Details
Main Authors: Chun-Shan Wu, Ching-Yun Chen, Chin-Hua Yang, Yu-Pao Hsu, Ching-Hsiao Yu, Yu-Hsu Chen, Shau-Kwaun Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-99772-5
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