Results and exploratory biomarker analyses of a phase II study CHANGEABLE: combination of HX008 and niraparib in GErm-line-mutAted metastatic breast cancer

Background: The combination of poly (ADP-ribose) polymerase inhibitors and immune-checkpoint inhibitors demonstrated synergistic antitumor activity in preclinical studies. We aim to investigate the efficacy, safety, and biomarker analyses of the combination of niraparib and PD-1 inhibitor HX008 in m...

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Bibliographic Details
Main Authors: Yizi Jin, Yiqun Du, Yanchun Meng, Xuchen Shao, Xiaojun Liu, Yuxin Mu, Yun Liu, Zhen Hu, Jian Zhang
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:The Lancet Regional Health. Western Pacific
Online Access:http://www.sciencedirect.com/science/article/pii/S2666606524003031
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