Integrated Proteomics and Metabolomics Reveal Spermine Enhances Sperm Freezability via Antioxidant Pathways

Integrated Proteomics and Metabolomics Reveal Spermine Enhances Sperm Freezability via Antioxidant Pathways

Sperm freezability exhibits marked individual variability, yet the mechanisms remain unclear. Using bulls as the experimental model, we integrated proteomic (sperm) and metabolomic (seminal plasma) analyses of high-freezability (HF) and control (CF) bulls to identify key biomarkers associated with s...

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Bibliographic Details
Main Authors: Lewei Guo, Zhuoxuan Gu, Bing Wang, Yunuo Wang, Jiaorong Chen, Yitong Li, Qiuju Zheng, Jing Zhao, He Ding, Hongyu Liu, Yi Fang, Jun Wang, Wenfa Lyu
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Antioxidants
Subjects:
sperm freezability
oxidative stress
spermine
proteomics
metabolomics
Online Access:https://www.mdpi.com/2076-3921/14/7/861
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