Novel Approaches for Concurrent Irradiation in Locally Advanced Cervical Cancer: Platinum Combinations, Non-Platinum-Containing Regimens, and Molecular Targeted Agents
Despite the available prevention and early detection strategies, squamous-cell carcinoma of the uterine cervix is still diagnosed as locally advanced disease in a considerable proportion of patients. As a potent sensitizer of cancer cells, cisplatin has been the “traditional partner” of external bea...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2013/536765 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567714246295552 |
|---|---|
| author | Giannis Mountzios Aspasia Soultati Dimitrios Pectasides Meletios A. Dimopoulos Christos A. Papadimitriou |
| author_facet | Giannis Mountzios Aspasia Soultati Dimitrios Pectasides Meletios A. Dimopoulos Christos A. Papadimitriou |
| author_sort | Giannis Mountzios |
| collection | DOAJ |
| description | Despite the available prevention and early detection strategies, squamous-cell carcinoma of the uterine cervix is still diagnosed as locally advanced disease in a considerable proportion of patients. As a potent sensitizer of cancer cells, cisplatin has been the “traditional partner” of external beam irradiation in this setting for more than two decades. Induction chemotherapy strategies followed by concurrent chemoradiation or surgery and preoperative concurrent chemoradiation have been recently implemented in clinical trials in an effort to optimize local control and to minimize the risk of distant metastases. In this context, cisplatin has been combined with a number of other potential radiosensitizers, including 5-fluorouracil, capecitabine, and gemcitabine. In patients resistant or intolerant to platinum compounds, numerous non-platinum-containing regimens have been developed, implementing various antimetabolites, taxanes, antineoplastic antibiotics, and topoisomerase II inhibitors. More recently, molecular agents targeting critical pathways in cervical malignant transformation are being assessed in early clinical trials in combination with external-beam irradiation. In the current work, we review the evolving role of cisplatin and other platinum compounds, either alone or in combination regimens, in the context of other potent radiosensitizers. The emerging role of molecular targeted agents, as candidate partners of external beam irradiation, is also discussed. |
| format | Article |
| id | doaj-art-307ada2ccce34bfb989a1485a03e70c5 |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-307ada2ccce34bfb989a1485a03e70c52025-02-03T01:00:37ZengWileyObstetrics and Gynecology International1687-95891687-95972013-01-01201310.1155/2013/536765536765Novel Approaches for Concurrent Irradiation in Locally Advanced Cervical Cancer: Platinum Combinations, Non-Platinum-Containing Regimens, and Molecular Targeted AgentsGiannis Mountzios0Aspasia Soultati1Dimitrios Pectasides2Meletios A. Dimopoulos3Christos A. Papadimitriou4Department of Medical Oncology and Translational Research, 251 Air Force General Hospital, Neo Psychiko, 154 51 Athens, GreeceDepartment of Medical Oncology and Translational Research, 251 Air Force General Hospital, Neo Psychiko, 154 51 Athens, GreeceSecond Department of Internal Medicine, University of Athens School of Medicine, “Hippocrateion” Hospital, 115 25 Athens, GreeceDepartment of Clinical Therapeutics, University of Athens School of Medicine, “Alexandra” University Hospital, 115 25 Athens, GreeceDepartment of Clinical Therapeutics, University of Athens School of Medicine, “Alexandra” University Hospital, 115 25 Athens, GreeceDespite the available prevention and early detection strategies, squamous-cell carcinoma of the uterine cervix is still diagnosed as locally advanced disease in a considerable proportion of patients. As a potent sensitizer of cancer cells, cisplatin has been the “traditional partner” of external beam irradiation in this setting for more than two decades. Induction chemotherapy strategies followed by concurrent chemoradiation or surgery and preoperative concurrent chemoradiation have been recently implemented in clinical trials in an effort to optimize local control and to minimize the risk of distant metastases. In this context, cisplatin has been combined with a number of other potential radiosensitizers, including 5-fluorouracil, capecitabine, and gemcitabine. In patients resistant or intolerant to platinum compounds, numerous non-platinum-containing regimens have been developed, implementing various antimetabolites, taxanes, antineoplastic antibiotics, and topoisomerase II inhibitors. More recently, molecular agents targeting critical pathways in cervical malignant transformation are being assessed in early clinical trials in combination with external-beam irradiation. In the current work, we review the evolving role of cisplatin and other platinum compounds, either alone or in combination regimens, in the context of other potent radiosensitizers. The emerging role of molecular targeted agents, as candidate partners of external beam irradiation, is also discussed.http://dx.doi.org/10.1155/2013/536765 |
| spellingShingle | Giannis Mountzios Aspasia Soultati Dimitrios Pectasides Meletios A. Dimopoulos Christos A. Papadimitriou Novel Approaches for Concurrent Irradiation in Locally Advanced Cervical Cancer: Platinum Combinations, Non-Platinum-Containing Regimens, and Molecular Targeted Agents Obstetrics and Gynecology International |
| title | Novel Approaches for Concurrent Irradiation in Locally Advanced Cervical Cancer: Platinum Combinations, Non-Platinum-Containing Regimens, and Molecular Targeted Agents |
| title_full | Novel Approaches for Concurrent Irradiation in Locally Advanced Cervical Cancer: Platinum Combinations, Non-Platinum-Containing Regimens, and Molecular Targeted Agents |
| title_fullStr | Novel Approaches for Concurrent Irradiation in Locally Advanced Cervical Cancer: Platinum Combinations, Non-Platinum-Containing Regimens, and Molecular Targeted Agents |
| title_full_unstemmed | Novel Approaches for Concurrent Irradiation in Locally Advanced Cervical Cancer: Platinum Combinations, Non-Platinum-Containing Regimens, and Molecular Targeted Agents |
| title_short | Novel Approaches for Concurrent Irradiation in Locally Advanced Cervical Cancer: Platinum Combinations, Non-Platinum-Containing Regimens, and Molecular Targeted Agents |
| title_sort | novel approaches for concurrent irradiation in locally advanced cervical cancer platinum combinations non platinum containing regimens and molecular targeted agents |
| url | http://dx.doi.org/10.1155/2013/536765 |
| work_keys_str_mv | AT giannismountzios novelapproachesforconcurrentirradiationinlocallyadvancedcervicalcancerplatinumcombinationsnonplatinumcontainingregimensandmoleculartargetedagents AT aspasiasoultati novelapproachesforconcurrentirradiationinlocallyadvancedcervicalcancerplatinumcombinationsnonplatinumcontainingregimensandmoleculartargetedagents AT dimitriospectasides novelapproachesforconcurrentirradiationinlocallyadvancedcervicalcancerplatinumcombinationsnonplatinumcontainingregimensandmoleculartargetedagents AT meletiosadimopoulos novelapproachesforconcurrentirradiationinlocallyadvancedcervicalcancerplatinumcombinationsnonplatinumcontainingregimensandmoleculartargetedagents AT christosapapadimitriou novelapproachesforconcurrentirradiationinlocallyadvancedcervicalcancerplatinumcombinationsnonplatinumcontainingregimensandmoleculartargetedagents |