SERT-Deficient Mice Fed Western Diet Reveal Altered Metabolic and Pro-Inflammatory Responses of the Liver: A Link to Abnormal Behaviors

SERT-Deficient Mice Fed Western Diet Reveal Altered Metabolic and Pro-Inflammatory Responses of the Liver: A Link to Abnormal Behaviors

Background: The inheritance of the short SLC6A4 allele, encoding the serotonin transporter (SERT) in humans, increases susceptibility to neuropsychiatric and metabolic disorders, with aging and female sex further exacerbating these conditions. Both central and peripheral mechanism...

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Main Authors: Raymond Cespuglio, Anna Gorlova, Konstantin Zabegalov, Kirill Chaprov, Evgeniy Svirin, Kseniia Sitdikova, Alisa Burova, Boris Shulgin, Ksenia Lebedeva, Alexei V. Deikin, Sergey Morozov, Tatyana Strekalova
Format: Article
Language:English
Published: IMR Press 2025-01-01
Series:Frontiers in Bioscience-Landmark
Subjects:
serotonin transporter (sert)
sert-/- mice
western diet
aging
impulsive behavior
insulin receptor
leptin receptor
liver steatosis
nitrosative stress
pro-inflammatory cytokines
Online Access:https://www.imrpress.com/journal/FBL/30/1/10.31083/FBL26778
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