Diabetic Distal Symmetrical Polyneuropathy: Correlation of Clinical, Laboratory, and Electrophysiologic Studies in Patients with Type 2 Diabetes Mellitus
This cross-sectional study is aimed at determining the prevalence of distal symmetrical polyneuropathy (DSPN) and diabetic peripheral neuropathic pain (DPNP) in participants with type 2 diabetes mellitus (T2DM); finding the risk factors for DSPN and DPNP via biochemical tests; and correlating DSPN a...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/6356459 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832546861825654784 |
|---|---|
| author | Yi-Ching Weng Sung-Sheng Tsai Rong-Kuo Lyu Chun-Che Chu Long-Sun Ro Ming-Feng Liao Hong-Shiu Chang Chiung-Mei Chen Jawl-Shan Hwang Hung-Chou Kuo |
| author_facet | Yi-Ching Weng Sung-Sheng Tsai Rong-Kuo Lyu Chun-Che Chu Long-Sun Ro Ming-Feng Liao Hong-Shiu Chang Chiung-Mei Chen Jawl-Shan Hwang Hung-Chou Kuo |
| author_sort | Yi-Ching Weng |
| collection | DOAJ |
| description | This cross-sectional study is aimed at determining the prevalence of distal symmetrical polyneuropathy (DSPN) and diabetic peripheral neuropathic pain (DPNP) in participants with type 2 diabetes mellitus (T2DM); finding the risk factors for DSPN and DPNP via biochemical tests; and correlating DSPN and DPNP with the results of electrophysiologic studies, quantitative sensory tests, and neurologic examination. The 145 participants with T2DM enrolled were divided into the DSPN (abnormal nerve conduction studies (NCS) with signs of polyneuropathy), subclinical DSPN (abnormal NCS without signs of polyneuropathy), minimal DSPN (normal NCS with signs of polyneuropathy), and no DSPN groups. The biochemical risk factors of diabetic peripheral neuropathy were investigated. Neurologic examinations, laboratory tests, NCS, vibration threshold tests, and thermal threshold tests were conducted. The modified Michigan Neuropathy Screening Instrument (mMNSI) and Douleur Neuropathique 4 were used to evaluate the severity of DSPN and DPNP, respectively. In all, 30% of participants had DSPN and 11% had DPNP. DSPN correlated strongly with male gender and higher glycohaemoglobin levels; NCS abnormality correlated with higher glycohaemoglobin levels; DSPN severity correlated with NCS of each stimulating nerve. DPNP commonly occurred with clinical and electrophysiologic evidence of DSPN. Symptomatic diabetic polyneuropathy significantly correlated with longer disease duration, higher glycohaemoglobin levels, and abnormal vibration tests. The thermal threshold test combined with nerve conduction tests could detect most of the patients with DSPN, subclinical DSPN, and minimal DSPN. Poor diabetic control was independently associated with the development of DSPN. DPNP was associated with DSPN. The combination of thermal threshold tests with NCS can potentially provide the diagnosis of DSPN. |
| format | Article |
| id | doaj-art-306fde95215c4084b68ca67dba6506e8 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-306fde95215c4084b68ca67dba6506e82025-02-03T06:46:40ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/63564596356459Diabetic Distal Symmetrical Polyneuropathy: Correlation of Clinical, Laboratory, and Electrophysiologic Studies in Patients with Type 2 Diabetes MellitusYi-Ching Weng0Sung-Sheng Tsai1Rong-Kuo Lyu2Chun-Che Chu3Long-Sun Ro4Ming-Feng Liao5Hong-Shiu Chang6Chiung-Mei Chen7Jawl-Shan Hwang8Hung-Chou Kuo9Department of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center and Chang Gung University College of Medicine, Taoyuan, TaiwanDepartment of Endocrinology, Chang Gung Memorial Hospital at Linkou Medical Center and Chang Gung University College of Medicine, Taoyuan, TaiwanDepartment of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center and Chang Gung University College of Medicine, Taoyuan, TaiwanDepartment of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center and Chang Gung University College of Medicine, Taoyuan, TaiwanDepartment of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center and Chang Gung University College of Medicine, Taoyuan, TaiwanDepartment of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center and Chang Gung University College of Medicine, Taoyuan, TaiwanDepartment of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center and Chang Gung University College of Medicine, Taoyuan, TaiwanDepartment of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center and Chang Gung University College of Medicine, Taoyuan, TaiwanDepartment of Endocrinology, Chang Gung Memorial Hospital at Linkou Medical Center and Chang Gung University College of Medicine, Taoyuan, TaiwanDepartment of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center and Chang Gung University College of Medicine, Taoyuan, TaiwanThis cross-sectional study is aimed at determining the prevalence of distal symmetrical polyneuropathy (DSPN) and diabetic peripheral neuropathic pain (DPNP) in participants with type 2 diabetes mellitus (T2DM); finding the risk factors for DSPN and DPNP via biochemical tests; and correlating DSPN and DPNP with the results of electrophysiologic studies, quantitative sensory tests, and neurologic examination. The 145 participants with T2DM enrolled were divided into the DSPN (abnormal nerve conduction studies (NCS) with signs of polyneuropathy), subclinical DSPN (abnormal NCS without signs of polyneuropathy), minimal DSPN (normal NCS with signs of polyneuropathy), and no DSPN groups. The biochemical risk factors of diabetic peripheral neuropathy were investigated. Neurologic examinations, laboratory tests, NCS, vibration threshold tests, and thermal threshold tests were conducted. The modified Michigan Neuropathy Screening Instrument (mMNSI) and Douleur Neuropathique 4 were used to evaluate the severity of DSPN and DPNP, respectively. In all, 30% of participants had DSPN and 11% had DPNP. DSPN correlated strongly with male gender and higher glycohaemoglobin levels; NCS abnormality correlated with higher glycohaemoglobin levels; DSPN severity correlated with NCS of each stimulating nerve. DPNP commonly occurred with clinical and electrophysiologic evidence of DSPN. Symptomatic diabetic polyneuropathy significantly correlated with longer disease duration, higher glycohaemoglobin levels, and abnormal vibration tests. The thermal threshold test combined with nerve conduction tests could detect most of the patients with DSPN, subclinical DSPN, and minimal DSPN. Poor diabetic control was independently associated with the development of DSPN. DPNP was associated with DSPN. The combination of thermal threshold tests with NCS can potentially provide the diagnosis of DSPN.http://dx.doi.org/10.1155/2020/6356459 |
| spellingShingle | Yi-Ching Weng Sung-Sheng Tsai Rong-Kuo Lyu Chun-Che Chu Long-Sun Ro Ming-Feng Liao Hong-Shiu Chang Chiung-Mei Chen Jawl-Shan Hwang Hung-Chou Kuo Diabetic Distal Symmetrical Polyneuropathy: Correlation of Clinical, Laboratory, and Electrophysiologic Studies in Patients with Type 2 Diabetes Mellitus Journal of Diabetes Research |
| title | Diabetic Distal Symmetrical Polyneuropathy: Correlation of Clinical, Laboratory, and Electrophysiologic Studies in Patients with Type 2 Diabetes Mellitus |
| title_full | Diabetic Distal Symmetrical Polyneuropathy: Correlation of Clinical, Laboratory, and Electrophysiologic Studies in Patients with Type 2 Diabetes Mellitus |
| title_fullStr | Diabetic Distal Symmetrical Polyneuropathy: Correlation of Clinical, Laboratory, and Electrophysiologic Studies in Patients with Type 2 Diabetes Mellitus |
| title_full_unstemmed | Diabetic Distal Symmetrical Polyneuropathy: Correlation of Clinical, Laboratory, and Electrophysiologic Studies in Patients with Type 2 Diabetes Mellitus |
| title_short | Diabetic Distal Symmetrical Polyneuropathy: Correlation of Clinical, Laboratory, and Electrophysiologic Studies in Patients with Type 2 Diabetes Mellitus |
| title_sort | diabetic distal symmetrical polyneuropathy correlation of clinical laboratory and electrophysiologic studies in patients with type 2 diabetes mellitus |
| url | http://dx.doi.org/10.1155/2020/6356459 |
| work_keys_str_mv | AT yichingweng diabeticdistalsymmetricalpolyneuropathycorrelationofclinicallaboratoryandelectrophysiologicstudiesinpatientswithtype2diabetesmellitus AT sungshengtsai diabeticdistalsymmetricalpolyneuropathycorrelationofclinicallaboratoryandelectrophysiologicstudiesinpatientswithtype2diabetesmellitus AT rongkuolyu diabeticdistalsymmetricalpolyneuropathycorrelationofclinicallaboratoryandelectrophysiologicstudiesinpatientswithtype2diabetesmellitus AT chunchechu diabeticdistalsymmetricalpolyneuropathycorrelationofclinicallaboratoryandelectrophysiologicstudiesinpatientswithtype2diabetesmellitus AT longsunro diabeticdistalsymmetricalpolyneuropathycorrelationofclinicallaboratoryandelectrophysiologicstudiesinpatientswithtype2diabetesmellitus AT mingfengliao diabeticdistalsymmetricalpolyneuropathycorrelationofclinicallaboratoryandelectrophysiologicstudiesinpatientswithtype2diabetesmellitus AT hongshiuchang diabeticdistalsymmetricalpolyneuropathycorrelationofclinicallaboratoryandelectrophysiologicstudiesinpatientswithtype2diabetesmellitus AT chiungmeichen diabeticdistalsymmetricalpolyneuropathycorrelationofclinicallaboratoryandelectrophysiologicstudiesinpatientswithtype2diabetesmellitus AT jawlshanhwang diabeticdistalsymmetricalpolyneuropathycorrelationofclinicallaboratoryandelectrophysiologicstudiesinpatientswithtype2diabetesmellitus AT hungchoukuo diabeticdistalsymmetricalpolyneuropathycorrelationofclinicallaboratoryandelectrophysiologicstudiesinpatientswithtype2diabetesmellitus |