A stretchable human lung‐on‐chip model of alveolar inflammation for evaluating anti‐inflammatory drug response

A stretchable human lung‐on‐chip model of alveolar inflammation for evaluating anti‐inflammatory drug response

Abstract This study describes a complex human in vitro model for evaluating anti‐inflammatory drug response in the alveoli that may contribute to the reduction of animal testing in the pre‐clinical stage of drug development. The model is based on the human alveolar epithelial cell line Arlo co‐cultu...

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Main Authors: Clémentine Richter, Lorenz Latta, Daria Harig, Patrick Carius, Janick D. Stucki, Nina Hobi, Andreas Hugi, Paul Schumacher, Tobias Krebs, Alexander Gamrekeli, Felix Stöckle, Klaus Urbschat, Galia Montalvo, Franziska Lautenschläger, Brigitta Loretz, Alberto Hidalgo, Nicole Schneider‐Daum, Claus‐Michael Lehr
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Bioengineering & Translational Medicine
Subjects:
3R
acute lung injury
aerosolization
cytokine storm
immuno‐competent
lung‐on‐chip
Online Access:https://doi.org/10.1002/btm2.10715
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https://doi.org/10.1002/btm2.10715

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